Foundational Trials Collection
Introducing our latest resource – Foundational Trials in Critical Care. Replacing our old Top 100 Trials, this new collection presents the trials that underpin modern intensive care practice.
All trials are fully appraised in the same systematic manner, allowing clinicians to easily follow every trial. If you are new to critical care, need a resource to guide those new to the field, or just want to refresh your knowledge, then enjoy reading our Foundational Trials Collection.
We’ll release one most days, starting with arguably the most impactful trial of them all – ARMA.

CCR Down Under 2025
Registration has opened for CCR Down Under in Melbourne, on December 9th and 10th, again at the Edge in Federation Square.
We aim to bring another set of fantastic international critical care trials to Australia. If you are interested in the science underlying clinical practice, this is the meeting for you.
We're delighted to be partnering once again with the Alfred Intensive Care Academic Centre, and this year, with Monash University.
If you missed the presentations last December, the presentations of the so far published trials are available here.


Latest Randomised Trials
- Jiao. Randomized Trial of Early vs Standard Renal Replacement Therapy in Patients With Acute Kidney Injury After Type A Aortic Dissection. Ann Thorac Surg 2025;120(1):17-24
- Shehabi. Postoperative 20% Albumin Infusion and Acute Kidney Injury in High-Risk Cardiac Surgery Patients: The ALBICS AKI Randomized Clinical Trial. JAMA Surg 2025;epublished June 11th
- Goret. Impact of Noninvasive Ventilation Before and After Cardiac Surgery for Preventing Cardiac and Pulmonary Complications. A Clinical Randomized Trial. Chest 2025;167(6):1727-1736
- Shah. Fifth Centile Versus 50th Centile Mean Blood Pressure Targets in Pediatric Septic Shock: A Randomized Controlled Trial. Crit Care Med 2025;epublished June 16th
Latest Meta Analyses
- Cao. Efficacy and safety of corticosteroids in critically ill patients: a systematic review and meta-analysis. BMC Anesthesiol 2025;25(1):319
- Song. Fluid resuscitation in adults with severe infection and sepsis: a systematic review and network meta-analysis. Front Med (Lausanne) 2025;12:1543586
- Chuang. Diagnostic performances of procalcitonin and C-reactive protein for sepsis: a systematic review and meta-analysis. Eur J Emerg Med 2025;32(4):248-258
- Diz. Effect of Treatment With Balanced Crystalloids Versus Normal Saline on the Mortality of Critically Ill Patients With and Without Traumatic Brain Injury: A Systematic Review and Meta-Analysis. Anesth Analg 2025;141(1):152-161
Latest Observational Studies
- Serpa-Neto. Regional Practice Variation in the Management of Renal Replacement Therapy Modalities in the STARRT-AKI Trial. Blood Purif 2025;epublished July 1st
- Sunthankar. Methylprednisolone for Infant Heart Surgery: Subpopulation Analyses of a Randomized Controlled Trial. Crit Care Med 2025;53(7):e1470-e1480
- Izawa. High Normocapnia and Better Functional Outcome in Patients Undergoing Venoarterial Extracorporeal Membrane Oxygenation After Out-of-Hospital Cardiac Arrest. Chest 2025;167(6):1639-1650
- Shekhar. Prehospital Cricothyrotomy for Emergency Airway Management. Chest 2025;167(6):1684-1686
Latest Guidelines
- 2025 ESVM Guidelines on interventional treatment of venous thromboembolism. Vasa 2025;epublished June 30th
- Forero-Delgadillo. Colombian consensus on the care of critically ill patients with suspected or confirmed severe yellow fever. Lancet Reg Health Am 2025;48:101144
- Adams. CALM ICU guidelines: Preliminary guidelines on non-pharmacological strategies for agitation in the ICU − A Delphi study. Intensive Crit Care Nurs 2025;90:104135
- Le Marechal. Detection, evaluation and management of the sequelae of infectious encephalitis in adults. Infectious Diseases Now 2025;epublished June 26th
Latest Narrative Reviews
- Fujishima. Current corticosteroid therapeutic strategy for community-acquired pneumonia in adults: indications, dosage, and timing. J Intensive Care 2025;13:37
- Noor. Point-of-Care Ultrasound Use in Hemodynamic Assessment. Biomedicines 2025;13:1426
- Russotto. Airway management in critically ill patients. BJA Education 2025;epublished June 30th
- Murugaiyan. Current trends in neurocritical care: a comprehensive review. J Neurocrit Care 2025;18(1):1-15
Latest Editorials
- Kentish-Barnes. Palliative care in the ICU: from oxymoron to standard of care. Intensive Care Med 2025;epublished June 25th
- Landoni. The arc of a life in critical care research—in memory of Professor Rinaldo Bellomo (1956–2025). Signa Vitae 2025;epublished June 17th
- Kentish-Barnes. Palliative care in the ICU: from oxymoron to standard of care. Intensive Care Med 2025;epublished June 25th
- MacLaren. Risk Factors for Stress-related UGIB: More than a Gut Feeling. Am J Respir Crit Care Med 2025;epublished June 25th
- Bellomo. Expanding the critical care collaboration between Australia, New Zealand, and Brazil: The role of journals. Crit Care Resusc 2025;27(2):100114
Latest Commentaries
- Caplan. Central venous pressure: current uses and prospects for an old parameter. Intensive Care Med 2025;epublished June 25th
- Gaudry. Renal replacement therapy. Intensive Care Med 2025;epublished June 25th
- Healy. Vulnerability through art: a path forward. Intensive Care Med 2025;epublished June 25th
CCR Content

Foundational Trials
We start a new section looking at the foundation trials in critical care and start with probably the most important trial yet in the field.
added July 2nd

Paper of the Day
Wednesday, July 2nd
Rello. Severe Legionnaires’ disease. Ann Intensive Care 2024;14:51
Join us to read one paper per day and cover the spectrum of critical care across 2025. Previous papers of the day are available here.

Newsletter 707
Critical Care Reviews Newsletter 707, bringing you the best critical care research and open access articles for the week June 23rd to 29th.
Subscriptions are available to individuals and departments.
added June 30th
CCR Meeting Talks
After 14 meetings, we have a huge collection of superb presentations. We'll showcase them here, one at a time.
CCR25
John Hinds Lecture
Prof John Myburgh delivers a remarkable John Hinds Lecture at the Critical Care Reviews Meeting 2025, titled Ukuthola Ubuhle