Journal Watch Latest

RCT

Lu. Efficacy and safety of minocycline in patients with acute ischaemic stroke (EMPHASIS): a multicentre, double-blind, randomised controlled trial. Lancet 2026;epublished January 30th

New: 🔴 CCR Summary & Critique

added February 9th

image: Shutterstock / Creativity lover

RCT

Broderick. Recombinant factor VIIa versus placebo for spontaneous intracerebral haemorrhage within 2 h of symptom onset (FASTEST): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial. Lancet 2026;epublished February 4th

New: 🔴 CCR Summary & Critique

added February 9th

image: Shutterstock / Yok_onepiece

Guideline

Hohmann. Clinical Guideline for Treating Acute Respiratory Insufficiency with Invasive Ventilation and Extracorporeal Membrane Oxygenation: Updated Evidence- Based Recommendations for Choosing Modes and Setting Parameters of Mechanical Ventilation. Respiration 2025;epublished December 11th

added February 9th

Guideline

Recommendations for Stress Ulcer Prophylaxis in Critically Ill Adults: A Contextualized Clinical Practice Guideline From the Saudi Critical Care Society and the Scandinavian Society of Anaesthesiology and Intensive Care Medicine, Endorsed by the Kuwait Anesthesia and Critical Care Society. Scand J Trauma Resusc Emerg Med 2026;epublished February 8th

added February 9th

RCT

Ma. Tenecteplase for Acute Non–Large Vessel Occlusion 4.5 to 24 Hours After Ischemic StrokeThe OPTION Randomized Clinical Trial. JAMA 2026;epublished February 5th

New: 🔴 CCR Summary & Critique

added February 9th

image: Shutterstock / Springsky

Editorial

Rocco. Foundational principles for young intensivists to drive better outcomes: the bedside application of physiology. Crit Care Sci 2026;38:e20260286

added February 5th

Editorial

Ortoleva. Clinical trials of physiological monitors: learning from the mistakes of the past. J Cardiothorac Vasc Anesth 2026;40(2):432-434

added February 5th

image: Shutterstock / BelezaPoy

Commentary

Hernandez. Update on acute respiratory failure. Intensive Care Med 2026;epublished January 28th

added January 28th

image: Shutterstock / Karan Bunjean

Editorial

Honore. Bicarbonate level in replacement fluid during CVVH: less is more!. Intensive Care Med 2026;epublished January 28th

added January 28th

image: Shutterstock / Hospital man

Editorial

Battaglini. Early mobilisation in the ICU: when one size no longer fits all. Intensive Care Med 2026;epublished January 28th

added January 28th

image: Shutterstock / WeStudio

Guideline

ELSO. 2025 ELSO Consensus Statement for the Provision and Management of Nutrition Therapy in Critically Ill Adult Patients Requiring Extracorporeal Membrane Oxygenation. ASAIO J 2026;72(2):99-110

added January 27th

image: Shutterstock / ME_Image

Narrative Reviews

Dewey. Resuscitative thoracotomy: What you need to know. J Trauma Acute Care Surg 2026;100(2):153-161

added January 27th

image: Shutterstock / Faisal-razakk

Guideline

2026 Guideline for the Early Management of Patients With Acute Ischemic Stroke: A Guideline From the American Heart Association/American Stroke Association. Stroke 2026;epublished January 26th

added January 26th

image: Shutterstock / Creativity-lover

Two bags of red cells hanging on a stand

Narrative Review

Tymen. Physiological determinants and the red blood cells transfusion decision-making process in non-bleeding critically ill patients: a comprehensive narrative review. Intensive Care Med 2026;epublished January 26th

added January 26th

image: Shutterstock / PIJITRA-PHOMKHAM

Editorial

von Groote. Sodium bicarbonate application for the treatment of acute metabolic acidosis: what we know and what we still don’t know. Intensive Care Med 2026;epublished January 26th

added January 26th

image: Shutterstock / Pitchyfoto

CCR Content

Paper of the Day

Colaianni-Alfonso. Physiological effects and clinical evidence of high-flow nasal cannula during acute exacerbation in COPD patients: A narrative review. J Intensive Med 2025;5(2):127-133

Monday, February 9th

Latest Trial Summary & Critique

added February 8th

Latest Foundational Trials

Here's our critique of the landmark TTM2 trial, complete with the video of the results presentation.

ACTiVE Trial

Prof Ary Serpa Neto (Melbourne) presents the results of the ACTiVE trial at CR Down Under 2025 in melbourne. ACTiVE investigates automated closed-loop ventilation in critically ill adults. Prof Danny McAuley (Belfast) delivers an independent editorial. Carol Hodgson (Melbourne) chairs a panel discussion between Anais Charles-Nelson (Melbourne), Shay McGuinness (Auckland) and Matthew Semler (Nashville).

added January 22nd

Trialists' Summary

Prof Ary Serpa Neto (Melbourne) summaries the ACTiVE trial, presnted at CCR Down Under 2025 in Melbourne

Papers

CCR Meeting Talks

After 14 meetings, we have a huge collection of superb presentations. We'll showcase them here, one at a time.

CCR18

EOLIA Trial

Prof Niall Ferguson (Toronto) presents the EOLIA trial, investigating extracorporeal membrane oxygenation (ECMO) in severe acute respiratory distress syndrome

added January 22nd

Journal Watch Latest

RCT

RCT

Guideline

Guideline

RCT

Editorial

Editorial

Commentary

Editorial

Editorial

Guideline

Narrative Reviews

Guideline

Narrative Review

Editorial

CCR Content

Paper of the Day

Latest Newsletter

Latest Trial Summary & Critique

Latest Foundational Trials

Highlighted Guideline

ACTiVE Trial

Trialists' Summary

Papers

CCR Meeting Talks

After 14 meetings, we have a huge collection of superb presentations. We'll showcase them here, one at a time.

CCR18

EOLIA Trial

Privacy Settings

Functional

Preferences