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Would you like to receive the latest critical care literature every weekend?
Get the Critical Care Reviews Newsletter - there's nothing else like it!
Latest Randomised Trials
- Matthay. Treatment with Allogenic Mesenchymal Stromal Cells for Moderate to Severe Acute Respiratory Distress Syndrome: A Double-Blind, Placebo-controlled, Multi-Center, Phase 2b Clinical Trial (STAT). Am J Respir Crit Care Med 2025;epublished Jul 29
- Vokuhl. Continuous versus bolus norepinephrine administration and arterial blood pressure stability during induction of general anaesthesia in high-risk noncardiac surgery patients: a randomised trial. Br J Anaesth 2025;epublished Jul 30
- Lorenz. ROBotic-assisted Early Mobilization in ventilated surgical critically ill patients (ROBEM-I)-A randomized, controlled, outcome-assessor-blinded pilot study. Anaesth Crit Care Pain Med 2025;44(4):101549
- Etges. Economic analysis of high-flow nasal oxygen compared with noninvasive ventilation in patients with acute respiratory failure: results from the RENOVATE Randomized Clinical Trial. Respir Med 2025;epublished July 29th
Last updated August 3rd
Latest Meta Analyses
- Pipek. Acetylcholinesterase Inhibitors for Delirium Prevention: A Systematic Review and Meta-Analysis. Crit Care Med 2025;epublished August 4th
- Das. The Impact of Inflammatory Biomarker Subphenotypes on Acute Respiratory Distress Syndrome Prognosis: A Systematic Review and Meta-analysis. Indian J Crit Care Med 2025;29(7):597-603
- Reginato. Intensive Blood Pressure Lowering for Intracerebral Hemorrhage: A Systematic Review and Updated Meta-analysis of Randomized Controlled Trials. Neurocrit Care 2025;epublished Jul 30
- Liu. Shorter versus longer-duration antibiotic treatments for immunocompetent patients with bloodstream infections: a systematic review and meta-analysis. eClinicalMedicine 2025;86:103397
- Duan. Is restriction of intravenous fluid beneficial for septic shock in ICU patients? A meta-analysis of randomized controlled trials. BMC Anesthesiol 2025;25:374
Last updated August 6th
Latest Observational Studies
- Takahashi. Decreased Clearance of Low-Density Lipoprotein Cholesterol is Causally Associate With Increased Mortality of Septic Shock. Crit Care Med 2025;epublished August 4th
- Parrilla-Gómez. Association of Breathing Effort With Survival in Patients With Acute Respiratory Distress Syndrome. Crit Care Med 2025;epublished August 4th
- Leong. An IV Sodium Bicarbonate Shortage in the Critically Ill: An Interrupted Time-Series Analysis. Crit Care Med 2025;epublished August 4th
- Vaidie. Effect of temporary suspension of chronic immunosuppressive drugs on day-90 mortality and ICU-acquired infections among critically Ill patients with solid organ transplant: a retrospective multicenter study. Intensive Care Med 2025;51:1442-1452
Last updated August 6th
Latest Guidelines
- Bain. Research Priorities for Noninvasive Sampling of the Lower Respiratory Tract during Acute Respiratory Failure: An Official American Thoracic Society Workshop Report. Ann Am Thorac Soc 2025;22(8):1101-1114
- Kollmar. Acute care of aneurysmal subarachnoid hemorrhage: practical consensus statement from a multidisciplinary group of German-speaking neurointensivists and neuroradiologists on behalf of the DIVI neurology section. Neurol Res Pract 2025;7:54
- Wallace. American Burn Association Clinical Practice Guideline on Blood Product Transfusion in Burn Care. J Burn Care Res 2025;epublished July 26th
- Best Management Practices on Temporary Mechanical Circulatory Support: Joint Consensus Report of the PeriOperative Quality Initiative and the Enhanced Recovery After Surgery Cardiac Society. Ann Thorac Surg 2025;120(2):225-243
- Use of extracorporeal membrane oxygenation in adult trauma patients with refractory acute cardiopulmonary failure: guideline from the Chinese society of extracorporeal life support 2025. Crit Care 2025;29:334
Last updated August 3rd
Latest Narrative Reviews
- Idowu. When Lightning Strikes the Heart. CHEST Crit Care 2025;3(3):100157
- Almuntashiri. Exploring pharmacological strategies in the management of ARDS: Efficacy, limitations, and future directions. J Crit Care Med 2025;11(3):208-220
- Boontoterm. The treatment and monitoring of aneurysmal subarachnoid hemorrhage in critically ill patients. Clin Crit Care 2025;33(1):e250016
- Vlok. Intra-arrest percutaneous stellate ganglion block: a scoping review. J Emerg Crit Care Med 2025;9:13
- Gerard. Is "pre-sepsis" the new sepsis? A narrative review. PLoS Pathog 2025;21(7):e1013372
Last updated August 6th
Latest Editorials
- Parotto. Re-evaluating the impact of mechanical ventilation strategies during cardiac surgery with cardiopulmonary bypass: work in progress. Intensive Care Med 2025;epublished August 4th
- van Regenmortel. Maintenance and resuscitation fluids for brain injury: keep them salty and not too sweet but mind the kidney. Intensive Care Med 2025;epublished July 29th
- Conway Morris. Syndromic diagnostics in pneumonia: the quest for impact continues. Intensive Care Med 2025;epublished July 28th
- Montgomery. Climate change impacts: survival on, and of, intensive care. Crit Care 2025;29:335
Last updated August 6th
Latest Commentaries
- Michard. Not all pulse contour algorithms are created equal. Crit Care 2025;29:336
- Michowitz. The ‘10 Commandments’ from the 2025 ESC/EHRA Clinical Consensus Statement on Indications for Conduction System Pacing (CSP). Eur Heart J 2025;46(29):2844–2846
- Foglia. Ten Steps to Improve Outcomes of In-Facility Neonatal Resuscitation. Resuscitation 2025;epublished July 31st
- Krishnan. Using the 2024 National Academies of Science, Engineering, and Medicine Definition of Long COVID: Implications for Pulmonary and Critical Care Medicine. Am J Respir Crit Care Med 2025;211(8):1391–1396
- Long. Balanced Crystalloids for Pediatric Sepsis and Septic Shock. Acad Emerg Med 2025;epublished July 28th
Last updated August 6th
CCR Down Under 2025

Registration has opened for CCR Down Under in Melbourne, on December 9th and 10th, again at the Edge in Federation Square.
We aim to bring another set of fantastic international critical care trials to Australia. If you are interested in the science underlying clinical practice, this is the meeting for you.
We're delighted to be partnering once again with the Alfred Intensive Care Academic Centre, and this year, with Monash University.
If you missed the presentations last December, the presentations of the so far published trials are available here.



CCR Content

Paper of the Day
Thursday, August 7th
Join us to read one paper per day and cover the spectrum of critical care across 2025. Previous papers of the day are available here.

Newsletter 712
Critical Care Reviews Newsletter 712, bringing you the best critical care research and open access articles for the week July 28th to August 3rd.
Subscriptions are available to individuals and departments.
added August 4th

Foundational Trials
We start a new section looking at the foundation trials in critical care and start with probably the most important trial yet in the field.
added July 15th

Highlighted Narrative Reviews
With thousands of open access narrative reviews listed across the website, CCR provides a comprehensive educational resource. We'll highlight one topic here every few days. Today, we look at Acute Kidney Injury
added July 15th

Highlighted Guidelines
Need a guideline, or just want to refresh your knowledge on the evidence-based management of a particular condition? We provide more up-to-date guidelines than any other critical care resource. have a look at our Burns guideline section
added July 13th
CCR Meeting Talks
After 14 meetings, we have a huge collection of superb presentations. We'll showcase them here, one at a time.
CCR24
The PRE-OXI Trial Results
Jonathan Casey and Kevin Gibbs present the results of the PRE-OXI trial at the Critical Care Reviews Meeting 2024, in Titanic Belfast. PRE-OXI investigated non-invasive ventilation for preoxygenation in emergency intubation in the critically ill.
Yonathan Freund delivers an independent editorial. Catriona Kelly chairs a panel discussion with Anthony Gordon, Sheila Myatra, Victoria Cornelius and Jan Gunst.
PRE-OXI was simultaneously published in the New England Journal of Medicine.
added July 21st