CCR Blog
Faith, Evidence and the Stars:
The ANDROMEDA‑SHOCK‑2 Trial
Was Galileo right about medicine too?
That observation can dethrone belief.
For two decades, sepsis resuscitation has orbited fixed targets — lactate, MAP, cardiac output —each a sun around which practice revolved.
ANDROMEDA-SHOCK-2 asks us to look again.
What if the periphery, not the centre, tells the truth?
A stopwatch, a microscope slide, a blood-pressure cuff — not machines, but method.
In 1,467 patients across 19 countries, a capillary refill-time algorithm shortened organ support in patients with septic shock, without changing survival — or perhaps not yet proving it.
A trial that stirs both head and heart: belief confronting empiricism, precision medicine guided, this time, by the light of the stars.
Added November 7th
EVERDAC Trial
ANDROMEDA-SHOCK 2
- ANDROMEDA-SHOCK-2 Investigators. Personalized Hemodynamic Resuscitation Targeting Capillary Refill Time in Early Septic Shock—the ANDROMEDA-SHOCK-2 Randomized Clinical Trial. JAMA 2025; epublished October 29th
- Editorial: Machado. Capillary Refill Time in Sepsis—Searching for the Holy Grail. JAMA 2025; epublished October 29th
SONIA Trial
BICARICU-2 Trial
- Jung. Sodium Bicarbonate for Severe Metabolic Acidemia and Acute Kidney Injury—the BICARICU-2 Randomized Clinical Trial. JAMA 2025; epublished October 29th
- Editorial: Kusirisin. Sodium Bicarbonate in Severe Acidemia and Acute Kidney Injury—Turning the Tide or Chasing a Myth? JAMA 2025; epublished October 29th
- Greif. European Resuscitation Council Guidelines 2025 Executive Summary. Resuscitation 2025;215(Suppl 1):110770
- Smyth. European Resuscitation Council Guidelines 2025 Adult Basic Life Support. Resuscitation 2025;215(Suppl 1):110771
- Soar. European Resuscitation Council Guidelines 2025 Adult Advanced Life Support. Resuscitation 2025;215(Suppl 1):110769
- Djakow. European Resuscitation Council Guidelines 2025 Paediatric Life Support. Resuscitation 2025;215(Suppl 1):110767
- Hogeveen. European Resuscitation Council Guidelines 2025 Newborn Resuscitation and Support of Transition of Infants at Birth. Resuscitation 2025;215(Suppl 1):110766
- Lott. European Resuscitation Council Guidelines 2025 Special Circumstances in Resuscitation. Resuscitation 2025;215(Suppl 1):110753
- Nolan. European Resuscitation Council and European Society of Intensive Care Medicine Guidelines 2025 Post-Resuscitation Care. Resuscitation 2025;215(Suppl 1):110809
- Djärv. European Resuscitation Council Guidelines 2025 First Aid. Resuscitation 2025;215(Suppl 1):110752
- Baldi. European Resuscitation Council Guidelines 2025 Epidemiology in Resuscitation. Resuscitation 2025;215(Suppl 1):110733
- Raffay. European Resuscitation Council Guidelines 2025 Ethics in Resuscitation. Resuscitation 2025;215(Suppl 1):110734
- Semeraro. European Resuscitation Council Guidelines 2025 System Saving Lives. Resuscitation 2025;215(Suppl 1):110821
- Nabecker. European Resuscitation Council Guidelines 2025 Education for Resuscitation. Resuscitation 2025;215(Suppl 1):110739
CCR Blog
Vitamin C - A Love Story
Vitamin C in critical illness has always hinted at more than scurvy’s salvation. From Lind’s lemons to Linus Pauling’s promise to an ICU cocktail that briefly looked like a cure, the arc swings between elegant biology and stubborn clinical reality. We track the enzymes and endothelium, the catecholamines and carnitine, and the redox alchemy that can both shield and scorch. Then we meet the trials—VITAMINS neutral, LOVIT unnerving—and ask why sepsis would not yield while burns, post-arrest care, and megadose strategies still tempt inquiry. This piece follows the CCR thread through Belfast to Melbourne, where VITaCCA may yet decide whether our romance with ascorbate is requited or finally unmasked.
Added October 16th
Guideline
Randomised Controlled Trial
Systematic Review & Meta Analysis
Systematic Review & Meta Analysis
Narrative Review
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