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CCR Down Under 2025

December 9th & 10th

Melbourne

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EVIDENCE Trial Results Presentation

Mark Dennis (Melbourne) and Brian Burns (Sydney) present the results of the EVIDENCE trial at Critical Care Reviews Down Under 2024 at The Edge, Melbourne. An independent editorial is delivered by Stephen Bernard (Melbourne). The panelists are Marion Campbell (Aberdeen), Kiran Shekar (Brisbane), Bridget Dicker (Auckland), and Jacob Steinmetz (Copenhagen). The session is chaired by Chris Nickson (Melbourne). The EVIDENCE trial investigated expediated out-of-hospital cardiac arrest care, including in-hospital ECMO and advanced CPR methods.

Lancet Respiratory Medicine Paper

Burns. Expedited transfer from the scene for refractory out-of-hospital cardiac arrest in Australia: a prospective, multicentre, parallel, open label, randomised clinical trial. Lancet Respir Med 2025;epublished August 22nd

Interview with the Trialists

Journal Watch Latest

AABB Red Cell Transfusion Guideline in Acute Myocardial Infarction

Recommendations

  • For hospitalized patients with AMI, the panel suggests a liberal red cell transfusion strategy when the hemoglobin concentration is less than 10 g/dL (conditional recommendation, low-certainty evidence).
  • A restrictive strategy of 7 to 8 g/dL may result in increased mortality in patients with AMI.
  • The direction of the recommendation for the liberal strategy was based on the great importance of mortality for patients.
  • The conditional recommendation was based on the low certainty of evidence and the competing consideration of blood supply conservation.

added August 19th

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Narrative Reviews

Frat. Noninvasive respiratory supports in ICU. Intensive Care Med 2025;51:1476–1489

added August 21st

image: Shutterstock / urbans
Transcranial doppler ultrasound

Narrative Review

Cashmore. Transcranial ultrasound in the critically ill patient: a narrative review. ICMx 2025;13:86 

added August 19th

image: Shutterstock / Chaikom

Narrative Review

Yamamoto. Mechanism of sepsis. J Mol Pathol 2025;6:18

added August 14th

image: Shutterstock / Kateryna Kon

Randomised Controlled Trial

TIGRIS Trial Result Press Release - Polymyxin B Hemoadsorption Therapy for Endotoxic Septic Shock

  • Results exceed prespecified primary endpoint of 95% posterior probability of benefit for PMX on 28-day mortality

added August 13th

image: Shutterstock / KILO LUX

CCR Meeting Talks

After 14 meetings, we have a huge collection of superb presentations. We'll showcase them here, one at a time.

CCR19

APROCCHSS Trial Review

Prof Djillali Annane (Paris) discusses the APROCCHSS trial, investigating fludrocortisone and hydrocortisone in septic shock.

added August 17th

CCR Content

Intubated, sedated ICU patient

Paper of the Day

Saturday, August 30th

Brakenridge. Multiple organ failure: What you need to know. J Trauma Acute Care Surg 2024;97(6):831-838

Join us to read one paper per day and cover the spectrum of critical care across 2025. Previous papers of the day are available here.

Have it emailed to you!

image: Shutterstock
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Newsletter 715

Critical Care Reviews Newsletter 715, bringing you the best critical care research and open access articles for the week August 18th to 24th.

Subscriptions are available to individuals and departments.

added August 24th

CRRT machine

Highlighted Narrative Reviews

With thousands of open access narrative reviews listed across the website, CCR provides a comprehensive educational resource. We'll highlight one topic here every few days. Today, we look at Acute Kidney Injury

added August 20th

Hydroxyethyl starch fluid hanging from a drip stand

Foundational Trials

Myburgh JA, Finfer S, Bellomo R, Billot L, Cass A, Gattas D, et al; CHEST Investigators; the Australian and New Zealand Intensive Care Society Clinical Trials Group. Hydroxyethyl Starch or Saline for Fluid Resuscitation in Intensive Care. N Engl J Med. 2012;367(20):1901–1911

It's the latest in our Foundational Trials collection, looking at the trials which underpin contemporary critical care practice

added August 19th

image: Shutterstock / Shellygraphy
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Highlighted Guidelines

Need a guideline, or just want to refresh your knowledge on the evidence-based management of a particular condition? We provide more up-to-date guidelines than any other critical care resource. Have a look at our ARDS Guideline section

added August 12th

image: Shutterstock / tungtaechit

CCR Down Under 2025

Registration has opened for CCR Down Under in Melbourne, on December 9th and 10th, again at the Edge in Federation Square.

We aim to bring another set of fantastic international critical care trials to Australia. If you are interested in the science underlying clinical practice, this is the meeting for you.

We're delighted to be partnering once again with the Alfred Intensive Care Academic Centre, and this year, with Monash University.

If you missed the presentations last December, the presentations of the so far published trials are available here.

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