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About
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Major Trials
Liver
Albumin
Cirrhosis
Spontaneous Bacterial Peritonitis
Infections
Fluids
Albumin
Cirrhosis
China. A Randomized Trial of Albumin Infusions in Hospitalized Patients with Cirrhosis. N Engl J Med 2021;384:808-817
Caraceni. Long‑term albumin administration in decompensated cirrhosis (ANSWER): an open‑label randomised trial. Lancet 2018;391(10138):2417‑2429
Spontaneous Bacterial Peritonitis
Sort. Effect of intravenous albumin on renal impairment and mortality in patients with cirrhosis and spontaneous bacterial peritonitis. N Engl J Med 1999;341:403–409
Infections
Guevara. Albumin for bacterial infections other than spontaneous bacterial peritonitis in cirrhosis. A randomized, controlled study. J Hepatol 2012;57:759–765
Hepatorenal Syndrome
Albumin
Wong. Terlipressin plus Albumin for the Treatment of Type 1 Hepatorenal Syndrome. N Engl J Med 2021; 384:818-828
Sanyal. A randomized, prospective, double‑blind, placebo‑controlled trial of terlipressin for type 1 hepatorenal syndrome. Gastroenterology 2008;134(5):1360‑1368
Upper GI Bleeding
TIPS
García‑Pagán. Early use of TIPS in patients with cirrhosis and variceal bleeding. N Engl J Med 2010;362(25):2370‑2379
Red Cell Transfusion
Villanueva. Transfusion strategies for acute upper gastrointestinal bleeding. N Engl J Med 2013;368(1):11‑21
Extracorporeal Support
Prometheus
Kribben. Effects of Fractionated Plasma Separation and Adsorption on Survival in Patients With Acute-on-Chronic Liver Failure (HELIOS study). Gastroenterology 2012;142(4)782-789
MARS
Bañares. Extracorporeal albumin dialysis with the molecular adsorbent recirculating system in acute‑on‑chronic liver failure: the RELIEF trial. Hepatology 2013;57(3):1153‑1162
N-Acetylcysteine
Paracetamol Liver Injury
Keays. Intravenous acetylcysteine in paracetamol induced fulminant hepatic failure: a prospective controlled trial. BMJ 1991;303:1026-1029
Non-Paracetamol Liver Injury
Darweesh. Effect of N-Acetylcysteine on Mortality and Liver Transplantation Rate in Non-Acetaminophen-Induced Acute Liver Failure: A Multicenter Study. Clin Drug Investig 2017;37:473–482
Lee. Intravenous N‑acetylcysteine improves transplant‑free survival in early stage non‑acetaminophen acute liver failure. Gastroenterology 2009;137(3):856‑864
Hypothermia
Acute Liver Failure
Bernal. A multicentre randomized controlled trial of moderate hypothermia to prevent intracranial hypertension in acute liver failure. J Hepatol 2016;65:273-279
Alcoholic Hepatitis
Antibiotics
Louvet. Effect of Prophylactic Antibiotics on Mortality in Severe Alcohol-Related Hepatitis. A Randomized Clinical Trial. JAMA 2023;329(18):1558-1566
Steroids
Thursz. Prednisolone or pentoxifylline for alcoholic hepatitis. N Engl J Med 2015;372(17):1619‑1628