Skip to main content

Major Trials

Liver

Albumin

Cirrhosis
Spontaneous Bacterial Peritonitis
Infections

Fluids

Albumin

Cirrhosis

China. A Randomized Trial of Albumin Infusions in Hospitalized Patients with Cirrhosis. N Engl J Med 2021;384:808-817

Spontaneous Bacterial Peritonitis

Sort. Effect of intravenous albumin on renal impairment and mortality in patients with cirrhosis and spontaneous bacterial peritonitis. N Engl J Med 1999;341:403–409

Infections

Guevara. Albumin for bacterial infections other than spontaneous bacterial peritonitis in cirrhosis. A randomized, controlled study. J Hepatol 2012;57:759–765

Hepatorenal Syndrome

Image: Shutterstock |

Albumin

Wong. Terlipressin plus Albumin for the Treatment of Type 1 Hepatorenal Syndrome. N Engl J Med 2021; 384:818-828

Extracorporeal Support

Image: Shutterstock |

Prometheus

Kribben. Effects of Fractionated Plasma Separation and Adsorption on Survival in Patients With Acute-on-Chronic Liver Failure (HELIOS study). Gastroenterology 2012;142(4)782-789

N-Acetylcysteine

Image: Shutterstock |

Paracetamol Liver Injury

Keays. Intravenous acetylcysteine in paracetamol induced fulminant hepatic failure: a prospective controlled trial. BMJ 1991;303:1026-1029

Image: Shutterstock |

Non-Paracetamol Liver Injury

Darweesh. Effect of N-Acetylcysteine on Mortality and Liver Transplantation Rate in Non-Acetaminophen-Induced Acute Liver Failure: A Multicenter Study. Clin Drug Investig 2017;37:473–482

Hypothermia

Acute Liver Failure

Bernal. A multicentre randomized controlled trial of moderate hypothermia to prevent intracranial hypertension in acute liver failure. J Hepatol 2016;65:273-279

Antibiotics

Alcoholic Hepatitis

Louvet. Effect of Prophylactic Antibiotics on Mortality in Severe Alcohol-Related Hepatitis. A Randomized Clinical Trial. JAMA 2023;329(18):1558-1566