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Newsletter 710  |  July 20th, 2025

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The First Trial to be Announced for CCR Down Under 2025 is RSI

Welcome to the 710th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.

The highlights of this week's edition are randomised controlled trials on inhaled isoflurane for the sedation of mechanically ventilated children in intensive care & the combined use of a multiplex PCR and serum procalcitonin to reduce antibiotic exposure in critically ill patients with community-acquired pneumonia; systematic reviews and meta analyses on the effect of blood pressure threshold on adverse outcomes in patients with acute spinal cord injury & intravenous bronchodilators in pediatric critical asthma; and observational studies on evaluating the generalisability of formulas used to set tidal volumes in mechanically ventilated patients & the epidemiology and outcomes of septic shock in Japan.

There are also guidelines on renal replacement therapy, nutrition, & community-acquired pneumonia; narrative reviews on post cardiac arrest brain injury & severe community-acquired pneumonia; editorials on spontaneous breathing trials & endothelial glycocalyx integrity as a prognostic key in sepsis; and commentaries on volatile agents & perioperative cardiac output monitoring.

If you only have time to read one review article this week, try this one on preventing acute kidney injury and its longer-term impact in the critically ill.

CCR Down Under 2025

The first trial to be announced for CCR Down Under 2025 is the RSI trial, comparing ketamine with etomidate for emergency tracheal intubation in critically ill adults. This is the latest major airway trial from the prolific American Pragmatic Critical Care Research Group, who have completed many major trials including PRE-OXI, DEVICE, & PREPARE II. Profs Jon Casey and Matthew Semler will be in Melbourne to present these results and discuss their implications. Will the long-standing controversy about etomidate-induced adrenal suppression finally be settled? Join us in Melbourne or online, December 9th and 10th (local time, UTC+11) to find out. Registration is open!

Research

Randomised Controlled Trials

Systematic Review & Meta Analyses

Observational Studies

Protocols

Guidelines

Reviews

Clinical

Neurological
Circulatory
Resuscitaton
Respiratory
Nutrition
Hepatobiliary
Renal
Endocrine
Sepsis & Infectious Diseases
Trauma
Toxicology
Paediatrics & Neonatology
Miscellaneous

Pre-Clinical

General Interest

I hope you find this newsletter useful.


Until next week

Rob 

 

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