Lee-anne Chapple (Adelaide), Matthew Summers (Adelaide), and Adam Deane (Melbourne) present the results of the TARGET Protein trial at the Critical Care Reviews Meeting 2025 in Titanic Belfast. An independent editorial is delivered by Angelique de Man (Amsterdam). The panelists are Monica Taljaard (Toronto), Zudin Puthucheary (London), Stephanie Parks Taylor (Michigan). The session is chaired by Peter McGuigan (Belfast).

Marion-Moseby Knappe and Niklas Nielsen (Lund, Sweden) summarise the TTM2 Brain Injury Biomarker study, from the TTM2 trial, at the Critical Care Reviews Meeting 2025, in Titanic Belfast.

Stephanie Parks Taylor (Michigan) presents the results of the ENCOMPASS trial at the Critical Care Reviews Meeting 2025 in Titanic Belfast. An independent editorial is delivered by Jo McPeake (Cambridge). The panelists are Monica Taljaard (Toronto), Lee-anne Chapple (Adelaide), and Fernando Zampieri (Edmonton). The session is chaired by Bronwen Connolly (Belfast). The ENCOMPASS trial evaluated a comprehensive care transition intervention for sepsis survivors. ENCOMPASS is presently unpublished.

Ewan Goligher (Toronto) and Martin Dres (Paris) present the results of the RESCUE 3 trial at the Critical Care Reviews Meeting 2025 in Titanic Belfast. An independent editorial is delivered by Zudin Puthucheary (London). The panelists are Marion Campbell (Aberdeen), Bodil Steen Rasmussen (Aalborg), and Daniel Martin (London). The session is chaired by Jon Silversides (Belfast). The RESCUE 3 trial investigated the impact of transvenous phrenic nerve stimulation on weaning from mechanical ventilation.

Daniel Martin (Plymouth) and Paul Mouncey (London) present the results of the UK-ROX trial at the Critical Care Reviews Meeting 2025 in Titanic Belfast. An independent editorial is delivered by Bodil Steen Rasmussen (Aalborg). The panelists are Elizabeth George (London), Karen Bosma (London, Ontario), and Angelique de Man (Amsterdam). The session is chaired by Peter McGuigan (Belfast). The UK-ROX trial examined conservative versus standard care oxygen therapy in critically ill patients receiving invasive mechanical ventilation.

Fabrizio Monaco (Milan), Valentina Ajello (Rome), and Giovanni Landoni (Milan) present the results of the ANH trial at the Critical Care Reviews Meeting 2025 in Titanic Belfast. An independent editorial is delivered by Ludhmila Hajjar (São Paulo). The panelists are Elizabeth George (London), Ewan Goligher (Toronto), and Andrew Klein (Cambridge). The session is chaired by Jon Silversides (Belfast). The ANH trial compared acute normovolemic haemodilution with usual care in adult cardiac surgery.

Lauralyn McIntyre (Ottawa) and Monica Taljaard (Ottawa) present the results of the FLUID trial at the Critical Care Reviews Meeting 2025 in Titanic Belfast. An independent editorial is delivered by John Myburgh (Sydney). The panelists are David Harrison (London), Kathryn Maitland (Kilifi), and Fernando Zampieri (Edmonton). The session is chaired by Darren Taichman (Philadelphia). The FLUID trial investigated the impact of lactated Ringer's solution versus 0.9% saline in hospitalised adults.

Kathryn Maitland (Kilifi), Elizabeth George (London), and Roberta Petrucci (Geneva) present the results of the GASTROSAM trial at the Critical Care Reviews Meeting 2025 in Titanic Belfast. An independent editorial is delivered by Arthur Kwizera (Kampala). The panelists are David Harrison (London), John Myburgh (Sydney), and Cornelius Sendagire (Kampala). The session is chaired by Bronwen Connolly (Belfast). The GASTROSAM trial investigated intravenous rehydration in African children with severe acute malnutrition with gastroenteritis

Stefano Turi (Milan), Marilena Marmiere (Milan), and Giovanni Landoni (Milan) present the results of the PRINCE trial at the Critical Care Reviews Meeting 2025 in Titanic Belfast. An independent editorial is delivered by Ludhmila Hajjar (São Paulo). The panelists are Ranjit Lall (London), Kenneth Baillie (Edinburgh), and Niall Ferguson (Toronto). The session is chaired by Kathy Rowan (London). The PRINCE trial explored the effect of remote ischemic preconditioning on myocardial injury in noncardiac surgery.

Karen Bosma (London, Ontario) and Myriam Lafreniere-Roula (Toronto) present the results of the PROMIZING trial at the Critical Care Reviews Meeting 2025 in Titanic Belfast. An independent editorial is delivered by Kenneth Baillie (Edinburgh). The panelists are Victoria Cornelius (London), Bodil Steen Rasmussen (Aalborg), and Andrew Udy (Melbourne). The session is chaired by Daniel Martin (Plymouth). The PROMIZING trial compared pressure support versus proportional assist ventilation in critically ill invasively mechanically ventilated patients.

Michaël Chassé (Montreal) and Jai Shankar (Halifax) present the results of the INdex trial at the Critical Care Reviews Meeting 2025 in Titanic Belfast. An independent editorial is delivered by Andrew Udy (Melbourne). The panelists are Marion Campbell (Aberdeen), Kathy Rowan (London), and Niklas Nielsen (Lund). The session is chaired by Chris Nutt (Belfast). The INdex study investigated the diagnostic accuracy of brain computed tomography perfusion and CT angiography compared with the clinical examination.