Foundational Trials Collection

After many months of preparation, we're delighted to release our Foundational Trials Collection.

250 critical care contemporary trials are summarised and critiqued in depth.

If you are new to the field, are undertaking exams, or just want to refresh your knowledge, this is an excellent place to start.

added February 17th

ARMA

Low tidal volume ventilation
HEMOTION

Transfusion thresholds in TBI
IABP-SHOCK II

Intraaortic balloon pump for myocardial infarction with cardiogenic shock
SAFE

Albumin vs Saline in ICU
ADRENAL

Hydrocortisone for septic shock
REVISE

PPI for gastric ulcer prophylaxis
RSI

Ketamine vs etomidate for rapid sequence intubation
BLING III

Beta lactam infusions in sepsis

Journal Watch Latest

Journal Watch

Newsletter

Subscribe

CT brain showing a large intra cerebral haemorrhage

Commentary

Sekhon. Hyperoxaemia in acute brain injured patients: too much of a good thing?. Intensive Care Med 2026;epublished February 17th

added February 17th

image: Shutterstock / Yok_onepiece

Narrative Reviews

Joosten. Intraoperative blood pressure management in noncardiac surgery: a narrative review based on current evidence. Intensive Care Med 2026;epublished February 17th

added February 17th

image: Shutterstock /

RCT

Lu. Efficacy and safety of minocycline in patients with acute ischaemic stroke (EMPHASIS): a multicentre, double-blind, randomised controlled trial. Lancet 2026;epublished January 30th

New: 🔴 CCR Summary & Critique

added February 9th

image: Shutterstock / Creativity lover

RCT

Broderick. Recombinant factor VIIa versus placebo for spontaneous intracerebral haemorrhage within 2 h of symptom onset (FASTEST): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial. Lancet 2026;epublished February 4th

New: 🔴 CCR Summary & Critique

added February 9th

image: Shutterstock / Yok_onepiece

Guideline

Hohmann. Clinical Guideline for Treating Acute Respiratory Insufficiency with Invasive Ventilation and Extracorporeal Membrane Oxygenation: Updated Evidence- Based Recommendations for Choosing Modes and Setting Parameters of Mechanical Ventilation. Respiration 2025;epublished December 11th

added February 9th

Guideline

Recommendations for Stress Ulcer Prophylaxis in Critically Ill Adults: A Contextualized Clinical Practice Guideline From the Saudi Critical Care Society and the Scandinavian Society of Anaesthesiology and Intensive Care Medicine, Endorsed by the Kuwait Anesthesia and Critical Care Society. Scand J Trauma Resusc Emerg Med 2026;epublished February 8th

added February 9th

RCT

Ma. Tenecteplase for Acute Non–Large Vessel Occlusion 4.5 to 24 Hours After Ischemic StrokeThe OPTION Randomized Clinical Trial. JAMA 2026;epublished February 5th

New: 🔴 CCR Summary & Critique

added February 9th

image: Shutterstock / Springsky

Editorial

Rocco. Foundational principles for young intensivists to drive better outcomes: the bedside application of physiology. Crit Care Sci 2026;38:e20260286

added February 5th

Editorial

Ortoleva. Clinical trials of physiological monitors: learning from the mistakes of the past. J Cardiothorac Vasc Anesth 2026;40(2):432-434

added February 5th

image: Shutterstock / BelezaPoy

Commentary

Hernandez. Update on acute respiratory failure. Intensive Care Med 2026;epublished January 28th

added January 28th

image: Shutterstock / Karan Bunjean

CCR Content

Paper of the Day

Adhikari. Assessment and management of dengue. BMJ 2025;388:e082639

Wednesday, February 18th

Latest Trial Summary & Critique

Broderick. Recombinant factor VIIa versus placebo for spontaneous intracerebral haemorrhage within 2 h of symptom onset (FASTEST): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial. Lancet 2026;epublished February 4th

added February 8th

Latest Foundational Trials

Here's our critique of the landmark TTM2 trial, complete with the video of the results presentation.

ACTiVE Trial

Prof Ary Serpa Neto (Melbourne) presents the results of the ACTiVE trial at CR Down Under 2025 in melbourne. ACTiVE investigates automated closed-loop ventilation in critically ill adults. Prof Danny McAuley (Belfast) delivers an independent editorial. Carol Hodgson (Melbourne) chairs a panel discussion between Anais Charles-Nelson (Melbourne), Shay McGuinness (Auckland) and Matthew Semler (Nashville).

added January 22nd

Trialists' Summary

Prof Ary Serpa Neto (Melbourne) summaries the ACTiVE trial, presnted at CCR Down Under 2025 in Melbourne

Foundational Trials Collection

Journal Watch Latest

Commentary

Narrative Reviews

RCT

RCT

Guideline

Guideline

RCT

Editorial

Editorial

Commentary

CCR Content

Paper of the Day

Latest Trial Summary & Critique

Latest Foundational Trials

ACTiVE Trial

Trialists' Summary

Papers

CCR Meeting Talks

After 14 meetings, we have a huge collection of superb presentations. We'll showcase them here, one at a time.

CCR18

EOLIA Trial

Foundational Trials Collection

Journal Watch Latest

Commentary

Narrative Reviews

RCT

RCT

Guideline

Guideline

RCT

Editorial

Editorial

Commentary

CCR Content

Paper of the Day

Latest Newsletter

Latest Trial Summary & Critique

Latest Foundational Trials

Highlighted Guideline

ACTiVE Trial

Trialists' Summary

Papers

CCR Meeting Talks

After 14 meetings, we have a huge collection of superb presentations. We'll showcase them here, one at a time.

CCR18

EOLIA Trial

Privacy Settings

Functional

Preferences

Statistics

Marketing