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CCR Down Under 2025

The Best Critical Care Trials in the World

Melbourne, December 9th - 10th

In Partnership With

Alfred Hospital Intensive Care Academic Centre and Monash University logos

Trials

ImmunoSep  |  CLIP II  |  ACTiVE  |  RSI

ImmunoSep Trial

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Prof Evangelos Giamarellos-Bourboulis (Athens) presents the results of the ImmunoSep trial at CCR Down Under 2025 in Melbourne. ImmunoSep investigates a precision medicine approach for immune modulation in sepsis. An independent editorial is delivered by Prof Sarah Sasson (Sydney). Prof Andrew Udy (Melbourne) chairs a panel discussion between Sandra Peake (Adelaide), Chris Seymour (Pittsburgh) and Jessica Kasza (Melbourne). The ImmunoSep trial was simultaneously published in JAMA on December 9th, 2025.

Papers

Trialists' Summary

Prof Evangelos Giamarellos-Bourboulis (Athens)

CLIP II Trial

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Prof Michael Reade (Brisbane) presents the results of the CLIP II trial at CCR Down Under 2025 in Melbourne. CLIP II compares cryopreserved platelets with liquid platelets for bleeding in cardiac surgery. Dr Elissa Milford (Brisbane) delivers an editorial. Prof Chris Seymour (Pittsbourgh) chairs a panel discussion between Liz Ryan (Melbourne), Jonathan Casey (Nashville) and Sant-Rayn Pasricha (Melbourne).

Papers

Trialists' Summary

Prof Michael Reade (Brisbane)

ACTiVE Trial

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Prof Ary Serpa Neto (Melbourne) presents the results of the ACTiVE trial at CR Down Under 2025 in melbourne. ACTiVE investigates automated closed-loop ventilation in critically ill adults. Prof Danny McAuley (Belfast) delivers an independent editorial. Carol Hodgson (Melbourne) chairs a panel discussion between Anais Charles-Nelson (Melbourne), Shay McGuinness (Auckland) and Matthew Semler (Nashville).

Papers

Trialists' Summary

Prof Ary Serpa Neto (Melbourne)

RSI Trial

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Jonathan Casey and Matthew Semler (Nashville) presents the results of the RSI trial at CCR Down Under 2025, in Melbourne. The RSI trial compared etomidate with ketamine for emergency intubation in the critically ill. Chris Nickson (Melbourne) delivers an independent editorial. Paul Young (Wellington) chairs a panel discussion between Wangari Waweru-Siika (Nairobi), Elissa Milford (Brisbane) and Liz Ryan (Melbourne). The RSI trial was simultaneous published in the New England Journal of Medicine.

Paper

Trialists' Summary

Profs Matthew Semler and Jonathan Casey (Nashville)

CCR Down Under 2025 Livestream

Presentations

The recordings of the presentations at CCR Down Under 2025 are now being edited. They will be posted shortly once they are finalised. The recordings of unpublished trials (iRehab, ARISE AFRICA, VITaCCA and ECMO REHAB) will be kept offline until they have been published.

added December 17th, 2025

Publications