Paracetamol Toxicity

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Wednesday, April 30th, 2025

Narrative Reviews

Paracetamol Toxicity

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Major Toxicology Trials | Major Paracetamol Guidelines

Sections

General | Monitoring & Investigations | Therapies

General

General

Li. Underlying mechanisms and treatment of acetaminophen‑induced liver injury. Mol Med Rep 2025;31(4):106
Chidiac. Paracetamol (acetaminophen) overdose and hepatotoxicity: mechanism, treatment, prevention measures, and estimates of burden of disease. Expert Opin Drug Metab Toxicol 2023;19(5):297-317

Analgesia

Freo. Paracetamol: A Review of Guideline Recommendations. J Clin Med 2021;10:3420

Background

Pathophysiology

Conditions

Liver Failure

Jaeschke. Acetaminophen Hepatotoxicity: Paradigm for Understanding Mechanisms of Drug-Induced Liver Injury. Annu Rev Pathol 2024;19:453-478

Complications

Complication

Monitoring & Investigations

Biomarkers

Umbaugh. Biomarkers of drug-induced liver injury: a mechanistic perspective through acetaminophen hepatotoxicity. Expert Rev Gastroenterol Hepatol 2021;15(4):363-375

Therapies

General

Akakpo. Novel strategies for the treatment of acetaminophen hepatotoxicity. Expert Opin Drug Metab Toxicol 2020;16(11):1039-1050

N-Acetylcysteine

Last updated March 5th, 2025