Critical Care Reviews Newsletter
Newsletter 479 | February 17th 2021
IL-6 Receptor Antagonist Domain Results Presentation is Imminent
Welcome to the 479th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature for the past seven days.
The highlights of this week's edition are the release of the preprint of the RECOVERY Collaborative Group's tocilizumab trial and an RCT investigating the effect of a restrictive vs liberal blood transfusion strategy in patients with acute myocardial infarction and anemia; a systematic review and meta analysis on the comparative effectiveness of protective ventilation strategies for moderate and severe ARDS; and an observational study comparing high-flow nasal oxygen therapy and non-invasive ventilation in ICU patients with acute respiratory failure and a do-not-intubate order. There is also a Chinese consensus statement on neuro-protection after cardiac arrest; narrative reviews on endovascular resuscitation & oxygen administration for patients with ARDS; an editorial on fever management in COVID-19 patients; & a commentary on optimizing secondary outcomes in randomized controlled trials.
The first of our Spring Series of major trial results is almost here, with the imminent relase of the REMAP-CAP IL-6 receptor antagonist domain results. Hopefully, we'll have this for you very shortly. The pre-print has already been published, but the full results are now almost ready for presentation.
Research
Randomised Controlled Trials
- Preprint: RECOVERY Collaborative Group. Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): preliminary results of a randomised, controlled, open-label, platform trial. MedRxiv 2021;epublished February 11th
- Ducrocq. Effect of a Restrictive vs Liberal Blood Transfusion Strategy on Major Cardiovascular Events Among Patients With Acute Myocardial Infarction and AnemiaThe REALITY Randomized Clinical Trial. JAMA 2021;325(6):552-560
- Maertens. Posaconazole versus voriconazole for primary treatment of invasive aspergillosis: a phase 3, randomised, controlled, non-inferiority trial. Lancet 2021;397(10273):499-509
- Holmberg. Ubiquinol (reduced Coenzyme Q10) as a Metabolic Resuscitator in Post-Cardiac Arrest: A Randomized, Double-Blind, Placebo-Controlled Trial. Resuscitation 2021;epublished February 8th
Systematic Reviews & Meta Analyses
- Yao. Anesthetic Induction With Etomidate in Cardiac Surgical Patients: A PRISMA-Compliant Systematic Review and Meta-Analysis. J Cardiothorac Vasc Anesth 2020;epublished December 2nd
- Lechtig-Wasserman. Carbapenem Therapeutic Drug Monitoring in Critically Ill Adult Patients and Clinical Outcomes: A Systematic Reviewwith Meta-Analysis. Antibiotics 2021;10: 177
- Sanfilippo. Cerebral regional oxygen saturation during cardiopulmonary resuscitation and return of spontaneous circulation: A systematic review and meta-analysis. Resuscitation 2021;159:19-27
- Sud. Comparative effectiveness of protective ventilation strategies for moderate and severe ARDS: Network meta-analysis. Am J Respir Crit Care Med epublished January 6th
- Liu. Role of dexmedetomidine in the treatment of delirium in critically ill patients: a systematic review and meta-analysis. Minerva Anestesiologica 2021;87(1):65-76
Observational Studies
- Thomsen. Association of α1-Blocker Receipt With 30-Day Mortality and Risk of Intensive Care Unit Admission Among Adults Hospitalized With Influenza or Pneumonia in Denmark. JAMA Netw Open 2021;4(2):e2037053
- Cortegiani. Albumin replacement therapy in immunocompromised patients with sepsis – Secondary analysis of the ALBIOS trial. J Crit Care Med 2021;epublished February 9th
- Garbez. A Loading Micafungin Dose in Critically Ill Patients Undergoing Continuous Veno-Venous Hemofiltration or Continuous Veno-Venous Hemodiafiltration. A Population Pharmacokinetic Analysis. Therapeutic Drug Monitoring 2021;epublished February 8th
- Robert. Comparison of high-flow nasal oxygen therapy and non-invasive ventilation in ICU patients with acute respiratory failure and a do-not-intubate orders: a multicentre prospective study OXYPAL. BMJ Open 2021;11(2):e045659
- Mellado-Artigas. High-flow nasal oxygen in patients with COVID-19-associated acute respiratory failure. Crit Care 2021;25:58
- Vandenbunder. Static compliance of the respiratory system in COVID-19 related ARDS: an international multicenter study. Crit Care 2021;25:52
- Thomsen. Association of α1-Blocker Receipt With 30-Day Mortality and Risk of Intensive Care Unit Admission Among Adults Hospitalized With Influenza or Pneumonia in Denmark. JAMA Netw Open 2021;4(2):e2037053
- Cortegiani. Albumin replacement therapy in immunocompromised patients with sepsis – Secondary analysis of the ALBIOS trial. J Crit Care Med 2021;epublished February 9th
- Garbez. A Loading Micafungin Dose in Critically Ill Patients Undergoing Continuous Veno-Venous Hemofiltration or Continuous Veno-Venous Hemodiafiltration. A Population Pharmacokinetic Analysis. Therapeutic Drug Monitoring 2021;epublished February 8th
Reviews
Clinical
COVID-19
- Fung. Similarities and Dissimilarities of COVID-19 and Other Coronavirus Diseases. Annual Review of Microbiology 2021;epublished January 25th
- Lopes-Pacheco. Pathogenesis of Multiple Organ Injury in COVID-19 and Potential Therapeutic Strategies. Front Physiol 2021;12:593223
- Masoomikarimi. Advances in immunotherapy for COVID-19: A comprehensive review. Int Immunopharmacol 2021;93:107409
- Martin-Loeches. Corticosteroids for CAP, influenza and COVID-19: when, how and benefits or harm? Eur Respir Rev 2021;30(159):200346
- Menezes. SARS-CoV-2 pneumonia—receptor binding and lung immunopathology: a narrative review. Crit Care 2021;25:53
- Rodriguez-Guerra. Current treatment in COVID-19 disease: a rapid review. Drugs Context 2021;10:2020-10-3
- Wang. Pregnancy and COVID-19: what anesthesiologists should know. Minerva Anestesiologica 2021;87(1):77-84
Neurological
Circulatory
- Lotz. Extracorporeal cardiopulmonary resuscitation: tool or toy? Minerva Anestesiologica 2021 January;87(1):101-5
- Madurska. State-of-the-Art Review—Endovascular Resuscitation. Shock 2021;55(3):288-300
- Visvanathan. Late development of Takotsubo syndrome following intensive care unit discharge. Neth J Crit Care 2021;29(1):14-21
- Rasmussen. Targeted Temperature Management for Treatment of Cardiac Arrest. Curr Treat Options Cardio Med 2020;22:39
Respiratory
Renal
Sepsis
Paediatrics
Perioperative
General Interest
Editorials
- Mooney. The Dangers of Ignoring History Lessons During a Pandemic. Ann Intern Med 2021;epublished February 9th
- Peluso. Fever management in COVID-19 patients. Minerva Anestesiologica 2021;87(1):1-3
- Deriy. Moving past Mallampati: airway ultrasound in predicting difficult face mask ventilation. Minerva Anestesiologica 2021;87(1):4-6
- Dodd. Anaphylaxis management — Why are guidelines inconsistent? A rapid review of advanced life support guidelines for cardiac arrest associated with anaphylaxis. Resuscitation 2021;159:165-167
- Bihari. Do more injured lungs need more protection: let’s test it. Am J Respir Crit Care Med 2021;epublished February 9th
Commentaries
- Kirby. COVID-19 survivor experiencing long-term symptoms. Lancet Respir Med 2021;epublished February 12th
- Nakkazi. Oxygen supplies and COVID-19 mortality in Africa. Lancet Respir Med 2021 February 10th
- Dal-Ré. Remdesivir for COVID-19 in Europe: will it provide value for money? Lancet Respir Med 2021;9(2):127-128
- Harahsheh. Optimizing the utility of secondary outcomes in randomized controlled trials. J Emerg Crit Care Med 2021;5:8
Correspondence
- Montrucchio. Are other effects of dexmedetomidine playing a role in explaining norepinephrine requirements decrease in septic shock patients? Minerva Anestesiologica 2021 January;87(1):107-8
- Mogavero. Direct oral anticoagulants perioperative management for “neuraxial block” in elective surgery. Minerva Anestesiologica 2021 January;87(1):109-10
- McGrath. Above cuff vocalization (ACV): an additional benefit of subglottic suction tracheostomy tubes. Minerva Anestesiologica 2021;87(1):113-4
- Bulatova. Early diagnosis of severe sepsis in children in the first year of life. Minerva Anestesiologica 2021;87(1):106-7
- Dargent. Septic shock, noradrenaline requirements and alpha-2 agonists: Fishing in the right pond?. Crit Care 2021;25:56
- Kritikos. Letter on “(1,3)-β-d-Glucan-based empirical antifungal interruption in suspected invasive candidiasis: a randomized trial”. Crit Care 2021;25:55
- Norii. Airway foreign body removal by a home vacuum cleaner: Findings of a multi-center registry in Japan. Resuscitation 2021;epublished February 14th
- Evora. Possible advances in vasopressors and inotropes support in shock. J Emerg Crit Care Med 2021;5:10
- Stevic. Lung Recruitability Evaluated by Recruitment-to-inflation Ratio and Lung Ultrasound in COVID-19 Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med 2021;epublished February 9th
Case Reports
- Yang. Central Venous Catheter Insertion in the Prone Position-A Last Resort in Critically Ill COVID-19 Patients. J Intensive Care Med 2021;36(3):373-375
- Lantinga. Jaundice due to autoimmune haemolytic anaemia in a patient with Gram-negative septic shock. Neth J Crit Care 2021;29(1):28-30
- Özbay. Leptospira-induced acute disseminated encephalomyelitis. Neth J Crit Care 2021;29(1):31-35
- Ibrahim. Treacher Collins syndrome: a case report. Neth J Crit Care 2021;29(1):36-40
- Smithuis. A case of cerebral and coronary air embolism after flushing of a pleural drain. Neth J Crit Care 2021;29(1):41-44
I hope you find this newsletter useful.
Until next week
Rob
Supported by the Health Research Board
