Welcome to the 490th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.
The highlights of this week's edition are the RECOVERY randomised controlled trial on tocilizumab in COVID-19 & a RCT on point-of-care ultrasound of the heart and lungs in patients with respiratory failure; systematic reviews and meta analyses on therapeutic hypothermia during cardiopulmonary resuscitation & prone positioning of nonintubated patients with COVID-2019; and observational studies on the association of delirium during critical illness with mortality & recall of clinical trial participation and attrition rates in survivors of acute respiratory distress syndrome.
There are also guidelines on admission criteria and management of critical care patients in a pandemic context & the management of hospitalised adults with COVID-19; narrative reviews on interleukin-6 receptor blockade in patients with COVID-19 & comprehensive haemodynamic assessment with ultrasound; editorials on a COASTal view: where prior beliefs and uncertainty collide & paediatric intensive care challenges caused by indirect effects of the COVID-19 pandemic; and commentaries on whether the Berlin definition of acute respiratory distress syndrome should include patients receiving high-flow nasal oxygen & incorporating adult evidence into pediatric research and practice; as well as correspondence on gender differences in the provision of intensive care & expanding controlled donation after the circulatory determination of death.
If you only have time to read one review article this week, try this one on pneumonia.
Research
Randomised Controlled Trials
- RECOVERY Collaborative Group. Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. Lancet 2021;397(10285):1637-1645
- Küçük. The effect of preemptive airway pressure release ventilation on patients with high risk for acute respiratory distress syndrome: a randomized controlled trial. Braz J Anesthesiol 2021;epublished April 24th
- Riishede. Point-of-care ultrasound of the heart and lungs in patients with respiratory failure: a pragmatic randomized controlled multicenter trial. Scand J Trauma Resusc Emerg Med 2021;29(1):60
- Kluger. Steroids to reduce the impact on delirium (STRIDE): a double‐blind, randomised, placebo‐controlled feasibility trial of pre‐operative dexamethasone in people with hip fracture. Anaesthesia 2021;epublished April 25th
- Singer. Enteral and supplemental parenteral nutrition enriched with omega-3 polyunsaturated fatty acids in intensive care patients - A randomized, controlled, double-blind clinical trial. Clin Nutr 2021;40(5):2544-2554
- Turra. Efficacy of speech therapy in post-intubation patients with oropharyngeal dysphagia: a randomized controlled trial. Codas 2021;33(2):e20190246
Systematic Review & Meta Analyses
- Ponnapa Reddy. Prone Positioning of Nonintubated Patients With Coronavirus Disease 2019-A Systematic Review and Meta-Analysis. Crit Care Med 2021;epublished April 30th
- Annoni. Impact of therapeutic hypothermia during cardiopulmonary resuscitation on neurologic outcome: A systematic review and meta-analysis. Resuscitation 2021;162:365-371
- Chang. Sodium bicarbonate administration during in-hospital pediatric cardiac arrest: A systematic review and meta-analysis. Resuscitation 2021;162:188-197
- Arango-Granados. Impact of red blood cell transfusion on oxygen transport and metabolism in patients with sepsis and septic shock: a systematic review and meta-analysis. Rev Bras Ter Intensiva 2021;33(1):154-166
- Jayasimhan. Cardiac biomarkers in acute respiratory distress syndrome: a systematic review and meta-analysis. J Intensive Care 2021;9:36
- Yasuda. Association of noninvasive respiratory support with mortality and intubation rates in acute respiratory failure: a systematic review and network meta-analysis. J Intensive Care 2021;9:32
- Almuwallad. The impact of prehospital TXA on mortality among bleeding trauma patients: A systematic review and meta-analysis. J Trauma Acute Care Surg 2021;90(5):901-907
- Zuo. Thrombolytic therapy for pulmonary embolism. Cochrane Database Syst Rev 2021;4:CD004437
- Bhatt. Early versus Late Initiation of Renal Replacement Therapy: Have We Reached the Consensus? An Updated Meta-Analysis. Nephron 2021;epublished April 29th
- Tleyjeh. Efficacy and safety of tocilizumab in COVID-19 patients: A living systematic Review and meta-analysis: first update. Clin Microbiol Infect 2021;epublished April 26th
Observational Studies
- See. US Case Reports of Cerebral Venous Sinus Thrombosis With Thrombocytopenia After Ad26.COV2.S Vaccination, March 2 to April 21, 2021. JAMA 2021;epublished April 30th
- Hughes. Association of Delirium during Critical Illness With Mortality: Multicenter Prospective Cohort Study. Anesth Analg 2021;epublished April 30th
- Lemkes. The effect of immediate coronary angiography after cardiac arrest without ST-segment elevation on left ventricular function. A sub-study of the COACT randomised trial. Resuscitation 2021;epublished April 28th
- Boede. Trajectories of depression in sepsis survivors: an observational cohort study. Crit Care 2021;25:161
- Carlton. Recall of clinical trial participation and attrition rates in survivors of acute respiratory distress syndrome. J Crit Care 2021;64:160-164
- Benichou. Vascular access for renal replacement therapy among 459 critically ill patients: a pragmatic analysis of the randomized AKIKI trial. Ann Intensive Care 2021;11:56
- Delorey. COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets. Nature 2021;epublished April 29th
Guidelines
- Admission criteria and management of critical care patients in a pandemic context: position of the Ethics Commission of the French Intensive Care Society, update of April 2021. Annals of Intensive Care 2021;11:66
- Chalmers. Management of hospitalised adults with coronavirus disease 2019 (COVID-19): a European Respiratory Society living guideline. Eur Respir J 2021;57(4)
- AARC Clinical Practice Guideline: Management of Adult Patients with Tracheostomy in the Acute Care Setting. Respir Care 2021;66(1):156-169
- Management of Congenital Diaphragmatic Hernia Treated With Extracorporeal Life Support: Interim Guidelines Consensus Statement From the Extracorporeal Life Support Organization. ASAIO J 2021;67(2):113-120
- First Brazilian recommendation on physiotherapy with sensory motor stimulation in newborns and infants in the intensive care unit. Rev Bras Ter Intensiva 2021;33(1):12-30
- P-COSCA (Pediatric Core Outcome Set for Cardiac Arrest) in Children. An Advisory Statement From the International Liaison Committee on Resuscitation. Resuscitation 2021;162:351-364
- Clinical staging of accidental hypothermia: The Revised Swiss System. Recommendation of the International Commission for Mountain Emergency Medicine (ICAR MedCom). Resuscitation 2021;162:182-187
Reviews
Clinical
COVID-19
- Angriman. Interleukin-6 receptor blockade in patients with COVID-19: placing clinical trials into context. Lancet Respir Med 2021;epublished April 27th
- Yang. Coronavirus diseases 2019 and kidney injury: a brief review based on current evidence. Chin Med J 2021;134(8):993–995
- Lim. Practical considerations for the operative team in performing tracheostomy during the COVID-19 pandemic. Singapore Med J 2021;62(4):204-206
- Wittenberg. Rapid development of a ventilator for use during the COVID-19 pandemic: Clinical, human factor & engineering considerations. JICS 2021;epublished April 19th
Circulatory
Respiratory
- Torres. Pneumonia. Nat Rev Dis Primers 2021;7:25
- Mastitskaya. Selective Vagus Nerve Stimulation as a Therapeutic Approach for the Treatment of ARDS: A Rationale for Neuro-Immunomodulation in COVID-19 Disease. Front Neurosci 2021;15:667036
Hepatobiliary
Renal
Sepsis
Trauma
Paediatrics
End-of-Life
- Takla. General anaesthesia in end‐of‐life care: extending the indications for anaesthesia beyond surgery. Anaesthesia 2021;epublished April 20th
- Maritz. Palliative medicine in intensive care unit during a pandemic. Lung India 2021;38:258-62
- Sady. Neuropalliative care: new perspectives of intensive care. Rev Bras Ter Intensiva 2021;33(1):146-153
Perioperative
Miscellaneous
Editorials
- Peters. A COASTal view: where prior beliefs and uncertainty collide. Intensive Care Med 2021;epublished April 27th
- Kanthimathinathan. Paediatric intensive care challenges caused by indirect effects of the COVID-19 pandemic. Intensive Care Med 2021;epublished April 27th
- Cecconi. Diversity and inclusivity: the way to multidisciplinary intensive care medicine in Europe. Intensive Care Med 2021;epublished April 29th
- Citerio. And once the storm is over… ICM will remain the intensivist’s beacon. Intensive Care Med 2021;epublished April 28th
- Kennedy-Metz. Importance of high-performing teams in the cardiovascular intensive care unit. J Thorac Cardiovasc Surg 2021;epublished March 31st
- Husain-Syed. COVID-19: spot urine rather than bronchoalveolar lavage fluid analysis? Crit Care 2021;25(1):162
Commentaries
- Matthay. The Berlin definition of acute respiratory distress syndrome: should patients receiving high-flow nasal oxygen be included? Lancet Respir Med 2021;epublished April 26th
- Murthy. Incorporating Adult Evidence Into Pediatric Research and Practice. Bayesian Designs to Expedite Obtaining Child-Specific Evidence. JAMA 2021;epublished April 26th
- Kadakia. Leveraging Open Science to Accelerate Research. N Engl J Med 2021;384:e61
- Perkis. Challenges in acute care surgery: penetrating vertebral artery injury in ‘extremis’ patient. Trauma Surgery & Acute Care Open 2021;6:e000684
- Cohn. Update in perioperative cardiac medicine 2021. Cleve Clin J Med 2021;88(4):216-220
- Badley. The Yin and Yang of SARS-CoV-2 Mutation and Evolution. Mayo Clin Proc 2021;96(4):863-865
- Dominelli. The Oxygen Cascade During Exercise in Health and Disease. Mayo Clin Proc 2021;96(4):1017-1032
Correspondence
- Todorov. Gender differences in the provision of intensive care: a Bayesian approach. Intensive Care Med 2021;epublished April 21st
- Müller. Expanding controlled donation after the circulatory determination of death: stronger emphasis on different cultural, religious and legal backgrounds is needed. Intensive Care Med 2021;epublished April 27th
- Trahtemberg. COVID-19-associated autoimmunity as a feature of acute respiratory failure. Intensive Care Med 2021;epublished April 30th
- Collins. A recurring case of ‘no trace, right place’ during emergency tracheal intubations in the critical care setting. Anaesthesia 2021;epublished April 19th
- Kelly. Oxygen enrichment in clinical areas using high‐flow nasal oxygen and non‐invasive respiratory support are provided. Anaesthesia 2021;epublished April 11th
- Stahl. Extracorporeal membrane oxygenation in non-intubated immunocompromised patients. Crit Care 2021;25(1):164
- Cammarota. PEEP-induced alveolar recruitment in patients with COVID-19 pneumonia: take the right time!. Crit Care 2021;25:163
- Kamata. Why participation in an international clinical trial platform matters during a pandemic? Launching REMAP-CAP in Japan. J Intensive Care 2021;9:34
- Goligher. Post-Extubation Respiratory Support: Of Clinical Trials and Clinical Decisions. Am J Respir Crit Care Med 2021;epublished April 26th
- Müller. Expanding controlled donation after the circulatory determination of death: stronger emphasis on different cultural, religious and legal backgrounds is needed. Intensive Care Med 2021;epublished April 27th
Case Reports
- Schmidt. Extracorporeal Membrane Oxygenation Instead of Invasive Mechanical Ventilation in a Patient with Severe COVID-19-associated Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med 2021;epublished April 26th
- Ramos. Simultaneous Imaging of Lung Perfusion and Glucose Metabolism in COVID-19 Pneumonia. Am J Respir Crit Care Med 2021;203(9):1186–1187