Critical Care Reviews Newsletter
Newsletter 497 | June 23rd 2021
The TTM2 Trial Results Livestream from Lund, Sweden
Welcome to the 497th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days. Apologies, it's slightly late, but it's been quite a week!
This week's newsletter is dominated by the landmark TTM2 trial results presentation, which we were fortunate to have the privilege to livestream last week. If you haven't yet either read the paper or watched the livestream, please do so. The results presentation was expertly delivered by chief investigator Niklas Nielsen, coordinating investigator Josef Dankiewicz, and long term follow up investigator Gisela Lilja. This was followed by a superb editorial by Stephen Bernard from Melbourne, the chief investigator of one of the original hypothermia trials 20 years ago. Questions from the audience were delivered by Phil Gillen. The session finished with a panel discussion including Jerry Nolan, an expert in resuscitation and cardiac arrest guideline formation, Kathy Rowan, the chair of the Data and Safety Monitoring Board for TTM2, and Terri Hough, an experienced intensivist and trialist, with an interest in long-term outcomes following critical illness.
If you have a question for the TTM2 team, please
Research
Randomised Controlled Trials
- Dankiewicz. Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest (TTM2 Trial). N Engl J Med 2021;384:2283-2294
- PRISM trial group. Postoperative continuous positive airway pressure to prevent pneumonia, re-intubation, and death after major abdominal surgery (PRISM): a multicentre, open-label, randomised, phase 3 trial. Lancet Respir Med 2021;epublished June 18th
- Arabi. Replacing protein via enteral nutrition in a stepwise approach in critically ill patients: A pilot randomized controlled trial (REPLENISH pilot trial). Clinical Nutrition ESPEN 2021;epublished June 2nd
- Rosén. Awake prone positioning in patients with hypoxemic respiratory failure due to COVID-19: the PROFLO multicenter randomized clinical trial. Crit Care 2021;25:209
- Aman. Imatinib in patients with severe COVID-19: a randomised, double-blind, placebo-controlled, clinical trial. Lancet Respir Med 2021;epublished June 17th
- Guimarães. Tofacitinib in Patients Hospitalized with Covid-19 Pneumonia. N Engl J med 2021;epublished June 16th
Systematic Reviews & Meta Analyses
Observational Studies
- Fukuda. Association between time to advanced airway management and neurologically favourable survival during out-of-hospital cardiac arrest. Anaesth Crit Care Pain Med 2021;epublished June 17th
- Ye. A systemic ultrasound positioning protocol for nasointestinal tube in critically ill patients. Crit Care 2021;25:213
- Tsolaki. Driving Pressure in COVID-19 ARDS is Associated with Respiratory Distress Duration Before Intubation. Am J Respir Crit Care Med 2021;epublished June 15th
- Robba. Intracranial pressure monitoring in patients with acute brain injury in the intensive care unit (SYNAPSE-ICU): an international, prospective observational cohort study. Lancet Neurology 2021;20(7):548-558
- Son. Multisystem Inflammatory Syndrome in Children — Initial Therapy and Outcomes. N Engl J Med 2021;epublished June 16th
- McArdle. Treatment of Multisystem Inflammatory Syndrome in Children. N Engl J Med 2021;epublished June 16th
Guidelines
- Mechanical Complications of Acute Myocardial Infarction: A Scientific Statement From the American Heart Association. Circulation 2021;epublished June 15th
- European Society of Radiology. The role of lung ultrasound in COVID-19 disease. Insights Imaging 2021;12(1):81
- Standardizing nomenclature in regional anesthesia: an ASRA-ESRA Delphi consensus study of abdominal wall, paraspinal, and chest wall blocks. Reg Anesth Pain Med 2021;46(7):571-580
- Law. Canadian Airway Focus Group updated consensus-based recommendations for management of the difficult airway: part 1. Difficult airway management encountered in an unconscious patient. Can J Anaesth 2021;epublished June 18th
- Malhotra. Second wave of COVID-19 pandemic and the surge of mucormycosis: Lessons learnt and future preparedness: Indian Society of Anaesthesiologists (ISA National) Advisory and Position Statement. Indian J Anaesth 2021;65:427-33
Reviews
COVID-19
- Ogawa. Non-invasive oxygenation strategies for respiratory failure with COVID-19: A concise narrative review of literature in pre and mid-COVID-19 era. Anaesth Crit Care Pain Med 2021;40(4):100897
- Battaglini. The Role of Dysbiosis in Critically Ill Patients With COVID-19 and Acute Respiratory Distress Syndrome. Front Med 2021;8:671714
- Duque-Rodríguez. The Therapeutic Use of Plasma from Covid-19 Convalescent Patients. Plasmatology 2021;epublished June 17th
- Fang. Immunothrombosis in Acute Respiratory Dysfunction of COVID-19. Front Immunol 2021;12:651545
Circulatory
Renal
Sepsis
Obstetrics
Toxicology
Paediatrics
- Sankaran. Non-invasive carbon dioxide monitoring in neonates: methods, benefits, and pitfalls. J Perinatol 2021;epublished June 19th
- Perret. Emergent Pneumonia in Children. Front Pediatr 2021;9:676296
- Piani. Acute Kidney Injury in Pediatric Diabetic Kidney Disease. Front Pediatr 2021;9:668033
- Wong. Pediatric sepsis biomarkers for prognostic and predictive enrichment. Pediatr Res 2021;epublished June 14th
Miscellaneous
Saudi Journal of Anaesthesia Series on Thoracic Anaesthesia
- Licker. The hypoxic pulmonary vasoconstriction: From physiology to clinical application in thoracic surgery. Saudi J Anaesth 2021;15:250-63
- Ellenberger. How can we minimize the risks by optimizing patient's condition shortly before thoracic surgery?. Saudi J Anaesth 2021;15:264-71
- Huybrechts. Lung separation in adult thoracic anesthesia. Saudi J Anaesth 2021;15:272-9
- Eldawlatly. Double lumen tube: Size and insertion depth. Saudi J Anaesth 2021;15:280-2
- Murray-Torres. Anesthesia for thoracic surgery in infants and children. Saudi J Anaesth 2021;15:283-99
- Khidr. Difficult lung separation. An insight into the challenges faced during COVID-19 pandemic. Saudi J Anaesth 2021;15:300-11
- Parab. Inhalational versus intravenous anesthetics during one lung ventilation in elective thoracic surgeries: A narrative review. Saudi J Anaesth 2021;15:312-23
- Licker. Restricted, optimized or liberal fluid strategy in thoracic surgery: A narrative review. Saudi J Anaesth 2021;15:324-34
- Khidr. Impact of regional analgesia techniques on the long-term clinical outcomes following thoracic surgery. Saudi J Anaesth 2021;15:335-40
- Mijatovic. Post-thoracotomy analgesia. Saudi J Anaesth 2021;15:341-7
- Senturk. Enhanced recovery after thoracic anesthesia. Saudi J Anaesth 2021;15:348-55
- Gonsette. Anesthesia for robotic thoracic surgery. Saudi J Anaesth 2021;15:356-61
- Aymerich. Non intubated video-assisted thoracoscopic lung resections (NI-VATS) in COVID times. Saudi J Anaesth 2021;15:362-7
- Khidr. Education in thoracic anesthesia. Lessons learned from the European Association of Cardiothoracic Anaesthesiology (EACTA) programs. Saudi J Anaesth 2021;15:368-74
Commentaries
- Bein. What’s new in intensive care: environmental sustainability. Intensive Care Med 2021;epublished June 19th
- Proulx. Chrysalis. Intensive Care Med 2021;epublished June 16th
- The European Society of Intensive Care Medicine. Reducing the global burden of sepsis: a positive legacy for the COVID-19 pandemic?. Intensive Care Med 2021;epublished June 16th
- Betello. Oesophageal balloon positioning by echocardiography to guide positive pressure ventilation. J Clin Monit Comput 2021;epublished June 20th
- Leentjens. COVID-19-associated coagulopathy and antithrombotic agents—lessons after 1 year. Lancet Haematology 2021;8(7):e524-e533
Correspondence
- Broman. Extracorporeal membrane oxygenation for COVID-19 during first and second waves. Lancet Respir Med 2021;epublished June 16th
- Proulx. Provision of critical care in austere conditions: staff, supplies and space. Intensive Care Med 2021;epublished June 18th
- Redant. Anti-Xa activity and hemorrhagic event: isn’t it time to consider time ?. Crit Care 2021;25:210
- Teja. Pinpointing the Cause of Variation in Mortality in COVID-19. Am J Respir Crit Care Med 2021;epublished June 17th
- Thrombotic Thrombocytopenia after ChAdOx1 nCoV-19 Vaccination. N Engl J Med 2021;epublished June 16th
- Sklar. Always Say Never: Why Studies of Timing of Invasive Ventilation Should Compare “Early versus Late/Never” as Opposed to “Early versus Late”. Am J Respir Crit Care Med 2021;epublished June 17th
- Stahl. Staying Awake in Severe ARDS – A Perspective on Immunocompromised Patients. Am J Respir Crit Care Med 2021;epublished June 17th
Case Reports
- Leuzinger-Dias. Prone Positioning Covid-19 Patients: A Double-Edged Sword—A Case Report of a Devastating Ocular Complication. Ophthalmol Ther 2021;epublished June 19th
- Rola. Clinical applications of the venous excess ultrasound (VExUS) score: conceptual review and case series. Ultrasound J 2021;13:32
- Barral. Thromboaspiration and fibrinolysis infusion for portomesenteric thrombosis after AstraZeneca COVID-19 vaccine administration. Intensive Care Med 2021;epublished June 16th
- Hibbert. Case 18-2021: An 81-Year-Old Man with Cough, Fever, and Shortness of Breath. N Engl J Med 2021;384:2332-2340
- Zhang. Case Report: Pink Urine Syndrome Following Exposure to Propofol: A Rare, Impressive but Benign Complication. Front Pharmacol 2021;12:686619