Latest Trial to be Added to the Critical Care Reviews Meeting 2022 Programme
Welcome to the 529th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.
The highlight of this week's edition is the long awaited publication of the RECOVERY-RS randomised controlled trial, investigating non-invasive respiratory support in patients with COVID-19-related hypoxaemic respiratory failure. We were fortunate to host the trial result presentation as a livestream back in August and the paper has now been published in JAMA. The other highlights include a systematic review and meta analysis comparing high-flow nasal oxygen with noninvasive ventilation in extubated patients, and observational studies on clinical outcomes among patients with 1-year survival following intensive care unit treatment for COVID-19 & corticosteroids as a risk factor for COVID-19-associated pulmonary aspergillosis in intensive care patients. There are also guidelines on levosimendan in intensive care and emergency medicine & COVID-19 in intensive care medicine; narrative reviews on ECPella & tracheobronchial injury; editorials on timing for initiating renal replacement therapy & difficult airway management in the cardiac operating room; and commentaries on light sedation for mechanically ventilated patients & clinical trial design during and beyond the pandemic; as well as correspondence on lung transplantation for Covid-19–related respiratory failure in the United States & the evolution of blood product use in trauma resuscitation.
If you only have time to read one review article this week, try this one on a guide to immunotherapy for COVID-19.
Critical Care Reviews Meeting 2022
The latest addition to the Critical Care Reviews Meeting 2022 is the FIRST-ABC trial, investigating the use of high flow nasal oxygen, in comparison with continuous positive airway pressure, for non-invasive respiratory support in critically ill children. This master protocol encompasses 2 randomised controlled trials. The first trial ("Step-Up") compares the use of HFNO with CPAP in acutely unwell children requiring non-invasive respiratory support. The second trial compares HFNO with CPAP in recently extubated children ("Step-Down"). Further information on this, and the other trials so far on the #CCR22 programme, can be found on the meeting webpage. Registration for #CCR22, on June 15th to 17th at Titanic Belfast, is open.
Research
Randomised Controlled Trials
- Perkins. Effect of Noninvasive Respiratory Strategies on Intubation or Mortality Among Patients With Acute Hypoxemic Respiratory Failure and COVID-19The RECOVERY-RS Randomized Clinical Trial. JAMA 2022;epublished January 24th
- Cocchi. Esmolol TO Treat The Hemodynamic Effects of Septic Shock: A Randomized Controlled Trial. Shock 2021;epublished December 27th
- Fitzgerald. The Steroid Therapy and Outcome of Parapneumonic Pleural Effusions (STOPPE): A Pilot Randomized Trial. Am J Respir Crit Care Med 2022;epublished January 24th
- Rosengrave. Intravenous vitamin C administration to patients with septic shock: a pilot randomised controlled trial. Crit Care 2022;26:26
Systematic Review & Meta Analyses
- Troxel. Association of Convalescent Plasma Treatment With Clinical Status in Patients Hospitalized With COVID-19A Meta-analysis. JAMA Netw Open 2022;5(1):e2147331
- Guo. Effects of high-flow nasal oxygen cannula versus other noninvasive ventilation in extubated patients: a systematic review and meta-analysis of randomized controlled trials. Expert Rev Respir Med 2022;16(1):109-119
- Slooff. Role of extracorporeal membrane oxygenation in pediatric cancer patients: a systematic review and meta-analysis of observational studies. Ann Intensive Care 2012;12:8
- Ramadanov. Intravascular Versus Surface Cooling in Patients Resuscitated From Cardiac Arrest. A Systematic Review and Network Meta-Analysis With Focus on Temperature Feedback. Crit Care Med 2022;epublished January 31st
- Haykal. Meta-Analysis of the Role of Intermittent Pneumatic Compression of the Lower Limbs to Prevent Venous Thromboembolism in Critically Ill Patients. Int J Low Extrem Wounds 2022;21(1):31-40
Observational Studies
- Kurihara. Clinical Characteristics and Outcomes of Patients With COVID-19–Associated Acute Respiratory Distress Syndrome Who Underwent Lung Transplant. JAMA 2022;epublished January 27th
- Leistner. Corticosteroids as risk factor for COVID-19-associated pulmonary aspergillosis in intensive care patients. Crit Care 2022;26:30
- Simkovich. Resources and Geographic Access to Care for Severe Pediatric Pneumonia in Four Resource-limited Settings. Am J Respir Crit Care Med 2022;205(2):183–197
- Taniguchi. Patient-Centered Outcomes Following COVID-19. Frailty and Disability Transitions in Critical Care Survivors. Crit Care Med 2022;epublished January 26th
- Seeliger. Intracranial Hemorrhages on Extracorporeal Membrane Oxygenation. Differences Between COVID-19 and Other Viral Acute Respiratory Distress Syndrome. Crit Care Med 2022;epublished January 12th
- Sullivan. Acute kidney injury in patients hospitalized with COVID-19 from the ISARIC WHO CCP-UK Study: a prospective, multicentre cohort study. Nephrol Dial Transplant 2022;37(2):271–284
- Heesakkers. Clinical Outcomes Among Patients With 1-Year Survival Following Intensive Care Unit Treatment for COVID-19. JAMA 2022;epublished January 24th
Guidelines
- Update of the recommendations of the Sociedade Portuguesa de Cuidados Intensivos and the Infection and Sepsis Group for the approach to COVID-19 in Intensive Care Medicine. Rev Bras Ter Intensiva 2021;33(4):487-536
- Girardis. Levosimendan in intensive care and emergency medicine: literature update and expert recommendations for optimal efficacy and safety. J Anesth Analg Crit Care 2022;2:4
Reviews
Clinical
COVID-19
- van de Veerdonk. A guide to immunotherapy for COVID-19. Nat Med 2022;28:39–50
- Ginestra. COVID-19 Critical Illness: A Data-Driven Review. Annu Rev Med 2022;73:95–111
- Oliveira. Noninvasive ventilation in patients with COVID-19 from the perspective of the risk of contamination: a narrative review. Expert Rev Respir Med 2022;16(1):67-77
- Cryer. Prothrombotic Milieu, Thrombotic Events and Prophylactic Anticoagulation in Hospitalized COVID-19 Positive Patients: A Review. Clin Appl Thromb Hemost 2022;28:10760296221074353
Neurological
- Longrois. How should dexmedetomidine and clonidine be prescribed in the critical care setting? Rev Bras Ter Intensiva 2021;33(4):600-615
- Smithard. Physical Restraint in the Critical Care Unit: A Narrative Review. New Bioeth 2022;epublished January 27th
- Pantoja-Ruiza. Cannabis and pain: a scoping review. Braz J Anesthesiol 2022;72(1):142-151
Circulatory
- Zhao. The mechanism of multiple organ dyfunction syndrome in patients with COVID-19. J Med Virol 2022;epublished January 27th
- Meani. ECPella: Concept, Physiology and Clinical Applications. J Cardiothorac Vasc Anesth 2022;36(2):557-566
Respiratory
- Boutros. Multidisciplinary management of tracheobronchial injury. Eur Respir Rev 2022;31(163):210126
Hepatobiliary
Sepsis
- Sweeney. Integrated Multiorgan Bedside Ultrasound for the Diagnosis and Management of Sepsis and Septic Shock. Semin Respir Crit Care Med 2021;42(05):641-649
- Póvoa. Which Biomarkers Can Be Used as Diagnostic Tools for Infection in Suspected Sepsis? Semin Respir Crit Care Med 2021;42(05):662-671
- Lazzaro. The Interplay between Host Defense, Infection, and Clinical Status in Septic Patients: A Narrative Review. Int J Mol Sci 2022;23(2):803
Trauma
- Lier. Emergency Blood Transfusion for Trauma and Perioperative Resuscitation: Standard of Care. Transfus Med Hemother 2021;48(6):366-376
- Jackson. Prehospital Plasma Transfusion: What Does the Literature Show? Transfus Med Hemother 2021;48:358–365
Paediatrics
Miscellaneous
Editorials
- Lupia. Live forever. Intensive Care Med 2022;epublished January 28th
- Yu. Timing for Initiating Renal Replacement Therapy in Patients with Acute Kidney Injury: Late is Better?. J Transl Crit Care Med 2022;4:2
- Patel. The Challenge of Difficult Airway Management in the Cardiac Operating Room. J Cardiothorac Vasc Anesth 2022;epublished January 28th
Commentaries
- De Castro. Pediatric delirium in times of COVID-19. Rev Bras Ter Intensiva 2021;33(4):483-486
- Tanaka. What every intensivist should know about light sedation for mechanically ventilated patients. Rev Bras Ter Intensiva 2021;33(4):480-482
- Watson. Rise of the preprint: how rapid data sharing during COVID-19 has changed science forever. Nat Med 2022;28:2–5
- The I-SPY COVID Consortium. Clinical trial design during and beyond the pandemic: the I-SPY COVID trial. Nat Med 2022;28:9–11
- Murphy. A Possible Role for Anti-idiotype Antibodies in SARS-CoV-2 Infection and Vaccination. N Engl J Med 2022;386:394-396
- Fouladpour. Poppy’s Final Lesson. JAMA 2022;327(4):325-326
- Soliman-Aboumarie. How-to: Focus Cardiac Ultrasound in acute settings. European Heart Journal - Cardiovascular Imaging 2022;23(2):150–153
- Luo. Proactive vs Reactive Machine Learning in Health CareLessons From the COVID-19 Pandemic. JAMA 2022;epublished January 27th
- Klompas. Preventing SARS-CoV-2 Transmission in Health Care Settings in the Context of the Omicron Variant. JAMA 2022;epublished January 24th
Correspondence
- Hillman. Barotrauma and COVID-19. Intensive Care Med 2022;epublished January 28th
- van Mol. Symptoms of psychological distress among bereaved relatives of deceased patients in the intensive care unit during the first COVID-19 wave. Intensive Care Med 2022;epublished January 28th
- Chong. Effects of prone and lateral positioning alternate in high-flow nasal cannula patients with severe COVID-19. Crit Care 2022;26:28
- Hilty. mRNA-based SARS-CoV-2 vaccination is associated with reduced ICU admission rate and disease severity in critically ill COVID-19 patients treated in Switzerland. Intensive Care Med 2022;epublished January 20th
- Montrucchio. Antimicrobial Prophylaxis in ECMO: Is the Debate Still Open? Ann Am Thorac Soc 2022;epublished January 26th
- Pajon. SARS-CoV-2 Omicron Variant Neutralization after mRNA-1273 Booster Vaccination. N Engl J Med 2022;epublished January 26th
- Roach. Lung Transplantation for Covid-19–Related Respiratory Failure in the United States. N Engl J Med 2022;epublished January 26th
- Takashita. Efficacy of Antibodies and Antiviral Drugs against Covid-19 Omicron Variant. N Engl J Med 2022;epublished January 26th
- Jain. High Circulating Plasma Soluble Receptor for Advanced Glycation End-Products in Early COVID-19–associated Acute Respiratory Distress Syndrome: Pathophysiological Significance? Am J Respir Crit Care Med 2022;205(2):254–256
- Yazer. The Evolution of Blood Product Use in Trauma Resuscitation: Change Has Come. Transfus Med Hemother 2021;48:377–380
Case Reports
- Camões. Super-refractory status epilepticus and ketogenic diet in intensive care: a series report. Rev Bras Ter Intensiva 2022;33(4):635-639
- Stavi. The Pressure Paradox: Abdominal Compression to Detect Lung Hyperinflation in COVID-19 Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med 2022;205(2):245-247
I hope you find this newsletter useful.
Until next week
Rob
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