Dr Jon Bishop presents the results of the RePHILL trial
Welcome to the 535th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.
The highlight of this week's edition is the publication of the RePHILL trial, investigating prehospital blood product transfusion in patients with traumatic haemorrhage. We hosted the results of this trial as a livestream last Monday - the recording can be viewed here.
The other highlights of this newsletter are a randomised controlled trial on the effects of physiologic point-of-care cardiopulmonary resuscitation training on survival in cardiac arrest in pediatric ICUs; systematic reviews and meta analyses on vitamin C in critically ill patients & tranexamic acid in gastrointestinal bleeding; observational studies on whole genome sequencing in patients with critical Covid-19 & the association of ICU admission and outcomes in sepsis and acute respiratory failure.
There is also a set of guidelines on prehospital airway management; narrative reviews on chest tube management & indirect calorimetry in patients with sepsis; a commentary on REBOA in post-partum haemorrhage; as well as correspondence on limitations of the ARDS criteria during high-flow oxygen or non-invasive ventilation & stimulating neural pathways to reduce mechanical ventilation–associated neurocognitive dysfunction.
If you only have time to read one review article this week, try this one on a biological definition of ARDS.
Critical Care Reviews Meeting 2022
Registration for CCR22, on June 15th to 17th at Titanic Belfast, is open. We have details of two superb panel discussions to announce this week.
Next Livestream
Our next livestream is due for the start of April. More details will be provided very soon.
Research
Randomised Controlled Trials
- Crombie. Resuscitation with blood products in patients with trauma-related haemorrhagic shock receiving prehospital care (RePHILL): a multicentre, open-label, randomised, controlled, phase 3 trial. Lancet Haematology 2022;epublished March 7th
- Human Development Collaborative Pediatric Critical Care Research Network Investigator Groups. Effect of Physiologic Point-of-Care Cardiopulmonary Resuscitation Training on Survival With Favorable Neurologic Outcome in Cardiac Arrest in Pediatric ICUs. A Randomized Clinical Trial. JAMA 2022;327(10):934-945
- Dean. A Pragmatic Stepped-wedge, Cluster-controlled Trial of Real-time Pneumonia Clinical Decision Support. Am J Respir Crit Care Med 2022;epublished March 7th
- Faustino. Effectiveness of combined non-pharmacological interventions in the prevention of delirium in critically ill patients: A randomized clinical trial. J Crit Care 2022;68:114-120
- He. Randomized controlled trial: neostigmine for intra-abdominal hypertension in acute pancreatitis. Crit Care 2022;26:52
- Markmann. Impact of Portable Normothermic Blood-Based Machine Perfusion on Outcomes of Liver TransplantThe OCS Liver PROTECT Randomized Clinical Trial. JAMA Surg 2022;157(3):189-198
- Lee. Continuous versus Intermittent Enteral Tube Feeding for Critically Ill Patients: A Prospective, Randomized Controlled Trial. Nutrients 2022;14(3):664
Systematic Review & Meta Analyses
- Dionne. Tranexamic Acid in Gastrointestinal Bleeding: A Systematic Review and Meta-Analysis. Crit Care Med 2022;50(3):e313-e319
- Patel. IV Vitamin C in Critically Ill Patients: A Systematic Review and Meta-Analysis. Crit Care Med 2022;50(3):e304-e312
- Wang. Physical Rehabilitation in the ICU: A Systematic Review and Meta-Analysis. Crit Care Med 2022;50(3):375-388
- Deliwala. Proton Pump Inhibitors Versus Histamine-2-Receptor Antagonists for Stress Ulcer Prophylaxis in Critically Ill Patients: A Meta-analysis and Trial Sequential Analysis. J Clin Gastroenterol 2022;56(3):204-217
- Xiao. The Efficacy and Safety of Early Renal Replacement Therapy in Critically Ill Patients With Acute Kidney Injury: A Meta-Analysis With Trial Sequential Analysis of Randomized Controlled Trials. Front Med 2022;9:820624
- Guo. Fluvoxamine for the Early Treatment of COVID-19: A Meta-analysis of Randomized Clinical Trials. Am J Trop Med Hyg 2022; epublished March 9th
- Griesel. Inhaled corticosteroids for the treatment of COVID-19. Cochrane Database Syst Rev 2022; epublished March 9th
- Allencherril. Etiologies of In-hospital cardiac arrest: a systematic review and meta-analysis. Resuscitation 2022; epublished March 9th
- Ojo. The Effects of Enteral Nutrition in Critically Ill Patients with COVID-19: A Systematic Review and Meta-Analysis. Nutrients 2022;14(5):1120
- Kampolis. Comparison of advanced closed-loop ventilation modes with pressure support ventilation for weaning from mechanical ventilation in adults: A systematic review and meta-analysis. J Crit Care 2022;68:1-9
- Onorato. Beta-lactam monotherapy or combination therapy for bloodstream infections or pneumonia due to Pseudomonas aeruginosa: a meta-analysis. Int J Antimicrobial Agents 2022;59(3):106512
- Aneman. Target temperature management following cardiac arrest: a systematic review and Bayesian meta-analysis. Crit Care 2022;26:58
Observational Studies
- Kousathanas.Whole genome sequencing reveals host factors underlying critical Covid-19. Nature 2022;epublished March 7th
- Kochanek. Comparison of Intracranial Pressure Measurements Before and After Hypertonic Saline or Mannitol Treatment in Children With Severe Traumatic Brain Injury. JAMA Netw Open 2022;5(3):e220891
- Verma. Associated Factors and Clinical Outcomes in Mechanical Circulatory Support use in Patients Undergoing High Risk On-Pump Cardiac Surgery: Insights from the LEVO-CTS trial. Am Heart J 2022;epublished March 7th
- Portuondo. Association Between Hospital Perioperative Quality and Long-term Survival After Noncardiac Surgery. JAMA Surg 2022;157(3):258-268
- Byrne. Association of Venous Thromboembolism Prophylaxis After Neurosurgical Intervention for Traumatic Brain Injury With Thromboembolic Complications, Repeated Neurosurgery, and Mortality. JAMA Surg 2022;157(3):e215794
- Demirjian. Predictive Accuracy of a Perioperative Laboratory Test–Based Prediction Model for Moderate to Severe Acute Kidney Injury After Cardiac Surgery. JAMA 2022;327(10):956-964
- Hodgson. Comparison of 6-Month Outcomes of COVID-19 vs Non-COVID-19 Survivors of Critical Illness. Am J Respir Crit Care Med 2022;epublished March 7th
- Roozeman. Prognostication using SpO2/FiO2 in invasively ventilated ICU patients with ARDS due to COVID-19 – Insights from the PRoVENT-COVID study. J Crit Care 2022;68:31-37
- Chua. Therapeutic drug monitoring of meropenem and piperacillin-tazobactam in the Singapore critically ill population – A prospective, multi-center, observational study (BLAST 1). J Crit Care 2022;68:107-113
- Nedergaard. Failure of non-sedation strategy in critically ill, mechanically ventilated patients - a retrospective, post-hoc analysis of the NONSEDA trial. J Crit Care 2022;68:66-71
- Hartog. Changes in communication of end-of-life decisions in European ICUs from 1999 to 2016 (Ethicus-2) - a prospective observational study. J Crit Care 2022;68:83-88
- Jeong. Extracorporeal Life-Support For Out-Of-Hospital Cardiac Arrest: A Nationwide Multicenter Study. Shock 2022;epublished March 10th
- Leisman. Alveolar, Endothelial, and Organ Injury Marker Dynamics in Severe COVID-19. Am J Respir Crit Care Med 2022;205(5)
- Anesi. Association of ICU Admission and Outcomes in Sepsis and Acute Respiratory Failure. Am J Respir Crit Care Med 2022;205(5)
Protocols
- Brown. Use of selective gut decontamination in critically ill children: protocol for the Paediatric Intensive Care and Infection Control (PICnIC) pilot study. BMJ Open 2022;12(3):e061838
- Ridley. Protocol summary and statistical analysis plan for Intensive Nutrition Therapy comparEd to usual care iN criTically ill adults (INTENT): a phase II randomised controlled trial. BMJ Open 2022;12(3):e050153
- Opgenorth. LIBERATE: a study protocol for midodrine for the early liberation from vasopressor support in the intensive care unit (LIBERATE): protocol for a randomized controlled trial. Trials 2022;23(1):194
Guidelines
- Prehospital Airway Management Training and Education: An NAEMSP Position Statement and Resource Document. 3-13
- Quality Management of Prehospital Airway Programs: An NAEMSP Position Statement and Resource Document. 14-22
- Lyng. Prehospital Manual Ventilation: An NAEMSP Position Statement and Resource Document. Prehosp Emerg Care 2022;26(sup1):23-31
- Prehospital Supraglottic Airways: An NAEMSP Position Statement and Resource Document. 32-41
- Prehospital Drug Assisted Airway Management: An NAEMSP Position Statement and Resource Document. 42-53
- Prehospital Cardiac Arrest Airway Management: An NAEMSP Position Statement and Resource Document. 54-63
- Prehospital Trauma Airway Management: An NAEMSP Position Statement and Resource Document. 64-71
- Optimizing Physiology During Prehospital Airway Management: An NAEMSP Position Statement and Resource Document. 72-79
- Prehospital Noninvasive Ventilation: An NAEMSP Position Statement and Resource Document. 80-87
- Prehospital Mechanical Ventilation: An NAEMSP Position Statement and Resource Document. 88-95
- Prehospital Surgical Airway Management: An NAEMSP Position Statement and Resource Document. 96-101
- Prehospital Pediatric Respiratory Distress and Airway Management Training and Education: An NAEMSP Position Statement and Resource Document. 102-110
- Quality Management of Prehospital Pediatric Respiratory Distress and Airway Programs: An NAEMSP Position Statement and Resource Document. 111-117
- Prehospital Pediatric Respiratory Distress and Airway Management Interventions: An NAEMSP Position Statement and Resource Document. 118-128
- Novel Technologies and Techniques for Prehospital Airway Management: An NAEMSP Position Statement and Resource Document. 129-136
Reviews
Clinical
Neurological
- Liu. Role of Dexmedetomidine in Aneurysmal Subarachnoid Hemorrhage: A Comprehensive Scoping Review. J Neurosurgical Anesthesiol 2022;34(2):176-182
- Szederjesi. Target Controlled Infusion: An Anaesthetic Technique Brought in ICU. J Crit Care Med 2022;8(1):3-5
Respiratory
- Anderson. Comprehensive Review of Chest Tube Management. A Review. JAMA Surg 2022;157(3):269-274
- Bos. Towards a biological definition of ARDS: are treatable traits the solution?. ICMx 2022;10:8
Hepatobiliary
Renal
Sepsis
- Wasyluk. Methodological Aspects of Indirect Calorimetry in Patients with Sepsis—Possibilities and Limitations. Nutrients 2022;14(5):930
- Ivanov. Emerging Antifungal Targets and Strategies. Int J Mol Sci 2022;23(5):2756
- Iijima. Exchange Transfusion in Neonatal Sepsis: A Narrative Literature Review of Pros and Cons. J Clin Med 2022;11(5):1240
Commentaries
- Brandeland. The Labor of Story Telling. JAMA 2022;327(10):925-926
- Brede. Resuscitative endovascular balloon occlusion of the aorta: the postpartum haemorrhage perspective. Crit Care 2022;26:57
- Rohatgi. Perioperative Cardiovascular Considerations Prior to Elective Noncardiac Surgery in Patients With a History of COVID-19. JAMA Surg 2022;157(3):187-188
Correspondence
- Heinsar. Add-on therapies in VA-ECMO for cardiogenic shock: the heart recovers, yet other organs suffer. J Cardiothorac Vasc Anesth 2022;epublished March 8th
- Hultström. Limitations of the ARDS criteria during high-flow oxygen or non-invasive ventilation: evidence from critically ill COVID-19 patients. Crit Care 2022;26:55
- Salimi. Stimulating Neural Pathways to Reduce Mechanical Ventilation–associated Neurocognitive Dysfunction. Am J Respir Crit Care Med 2022;205(5):588–589
- Marrazzo. Effects of Trunk Inclination on Respiratory Mechanics in Patients with COVID-19–associated Acute Respiratory Distress Syndrome: Let’s Always Report the Angle!
I hope you find this newsletter useful.
Until next week
Rob
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