Dr Padmanabhan Ramnarayan presents the FIRST-ABC trial results at CCR22
Welcome to the 555th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature for the week of July 25th to 31st. Finally, we've caught up!
The highlights of this week's edition are randomised controlled trials on dosing strategies of tranexamic acid for red blood cell transfusion in patients undergoing cardiac surgery & preoperative antithrombin supplementation in patients at risk for antithrombin deficiency after cardiac surgery.; systematic reviews and meta analyses on high versus low dose corticosteroids in COVID-19 patients & Intensive Care Unit diaries; and observational studies on endotypes of traumatic brain injury & long-term cognitive function in ICU-treated COVID-19 patients. There is also a consensus statement on advanced bleeding control in combat casualty care; narrative reviews on inhaled sedation in the intensive care unit & the myths and misconceptions of airway pressure release ventilation; editorials on sensitivity analysis in clinical trials & SARS-CoV-2 vaccination efficacy on hospitalisation and variants; as well as commentaries on the evolution of sedation management in the ICU & lung and diaphragm protective ventilation guided by esophageal pressure.
If you only have time to read one review article this week, try this one on the physiological and pathophysiological consequences of mechanical ventilation.
CCR22 Videos
The videos from CCR22 continue to be released, with the FIRST-ABC trial result presentation the latest to be posted. Our latest visual abstract from Jakub Fronczek is on the CLASSIC trial.
Research
Randomised Controlled Trials
- Shi. Effect of High- vs Low-Dose Tranexamic Acid Infusion on Need for Red Blood Cell Transfusion and Adverse Events in Patients Undergoing Cardiac SurgeryThe OPTIMAL Randomized Clinical Trial. JAMA 2022;328(4):336-347
- Moront. A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of Preoperative Antithrombin Supplementation in Patients at Risk for Antithrombin Deficiency After Cardiac Surgery. Anesth Analg 2022;epublished July 25th
- Yu. Sugammadex Versus Neostigmine for Neuromuscular Block Reversal and Postoperative Pulmonary Complications in Patients Undergoing Resection of Lung Cancer. J Cardiothor Vasc Anaesth 2022;36(9):3626-3633
- Tripathy. Timing of Exposure to ICU Diaries and Its Impact on Mental Health, Memories, and Quality of Life: A Double-Blind Randomized Control Trial. Crit Care Explor 2022;4(8):e0742
Systematic Review & Meta Analyses
- Tan. High-Dose versus Low-Dose Corticosteroids in COVID-19 Patients: a Systematic Review and Meta-analysis. J Cardiothor Vasc Anaesth 2022;36(9):3576-3586
- Gazzato. The Effect of Intensive Care Unit Diaries on Posttraumatic Stress Disorder, Anxiety, and Depression: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Dimens Crit Care Nurs 2022 Sep-Oct;41(5):256-263
Observational Studies
- Cashen. Sodium Bicarbonate Use During Pediatric Cardiopulmonary Resuscitation: A Secondary Analysis of the ICU-RESUScitation Project Trial. Pediatr Crit Care Med 2022;epublished July 26th
- Ollila. Long-term cognitive functioning is impaired in ICU-treated COVID-19 patients: a comprehensive controlled neuropsychological study. Crit Care 2022;26:223
- Åkerlund. Clustering identifies endotypes of traumatic brain injury in an intensive care cohort: a CENTER-TBI study. Crit Care 2022;26:228
- Iwase. Prediction algorithm for ICU mortality and length of stay using machine learning. Sci Rep 2022;12(1):12912
- van Diepen. Efficacy and safety of proton pump inhibitors versus histamine-2 receptor blockers in the cardiac surgical population: insights from the PEPTIC trial. Eur J Cardiothorac Surg 2022;62(2):ezac124
Reviews
Clinical
COVID-19
Neurological
- Jabaudon. Inhaled sedation in the intensive care unit. Anaesth Crit Care Pain Med 2022;41(5):101133
- Dean. The O2-sensitive brain stem, hyperoxic hyperventilation, and CNS oxygen toxicity. Front Physiol 2022;13:921470
- Martinez-Vazquez. Different perspectives for monitoring nociception during general anesthesia. Korean J Anesthesiol 2022;75(2):112-123
- Shin. How general anesthetics work: from the perspective of reorganized connections within the brain. Korean J Anesthesiol 2022;75(2):124-138
- Kim. Remimazolam – current knowledge on a new intravenous benzodiazepine anesthetic agent. Korean J Anesthesiol 2022;75(4):307-315
Circulatory
- Winiszewski. Optimizing PO2 during peripheral veno-arterial ECMO: a narrative review. Crit Care 2022;26:226
- Zhou. Pyruvate as a Potential Beneficial Anion in Resuscitation Fluids. Front Med 2022;9:905978
- Jung. Therapeutic hypothermia for acute myocardial infarction: a narrative review of evidence from animal and clinical studies. Korean J Anesthesiol 2022;75(3):216-230
Respiratory
- Andrews. Myths and Misconceptions of Airway Pressure Release Ventilation: Getting Past the Noise and on to the Signal. Front Physiol 2022;13:928562
- Silva. Physiological and Pathophysiological Consequences of Mechanical Ventilation. Semin Respir Crit Care Med 2022;43(03):321-334
- Biselli. Lung Mechanics Over the Century: From Bench to Bedside and Back to Bench. Front Physiol 2022;13:817263
- Winiszewski. Optimizing PO2 during peripheral veno-arterial ECMO: a narrative review. Crit Care 2022;26:226
Hepatobiliary
Renal
Haematological
Sepsis
- Reddy. Fungal infections: Pathogenesis, antifungals and alternate treatment approaches. Curr Res Microb Sci 2022;3:100137
- Dilworth. β-Lactam Therapeutic Drug Monitoring in Critically Ill Patients: Weighing the Challenges and Opportunities to Assess Clinical Value. Crit Care Explor 2022;4(7):e0726
- Sheikh. Social Determinants of Health Associated With the Development of Sepsis in Adults: A Scoping Review. Crit Care Explor 2022;4(7):e0731
Perioperative
- Yoon. Artificial intelligence in perioperative medicine: a narrative review. Korean J Anesthesiol 2022;75(3):202-215
- Kim. Anatomical classification and clinical application of thoracic paraspinal blocks. Korean J Anesthesiol 2022;75(4):295-306
Miscellaneous
- Owen. Mechanisms of Post-critical Illness Cardiovascular Disease. Front Cardiovasc Med 2022;9:854421
Non-Clinical
Editorials
- Sanfilippo. The COVID-19 pandemic: a gateway between one world and the next! Anaesth Crit Care Pain Med 2022;41(5):101131
- The Intensive Care Committee of the French Society of Anaesthesia and Intensive Care Medicine. Invention of intensive care medicine by an anaesthesiologist: 70 years of progress from epidemics to resilience to exceptional healthcare crises. Anaesth Crit Care Pain Med 2022;41(5):101115
- Rozencwajg. SARS-CoV-2 vaccination efficacy on hospitalisation and variants. Anaesth Crit Care Pain Med 2022;41(5):100867
- Ghiya. What's new in emergencies, trauma and shock – Burnout in emergency physicians. J Emerg Trauma Shock 2022;15:75-6
- Roques. The other opioid crisis: the situation in low-resource countries. Can J Anesth 2022;69:923–929
- Parpia. Sensitivity analysis in clinical trials: three criteria for a valid sensitivity analysis. Eye 2022;epublished May 18th
- Chang. The 5 min meta-analysis: understanding how to read and interpret a forest plot. Eye 2022;36:673–675
Commentaries
- Stollings. Evolution of sedation management in the intensive care unit (ICU). Intensive Care Med 2022;epublished July 29th
- Chanques. Monitoring pain in the intensive care unit (ICU). Intensive Care Med 2022;epublished July 29th
- Chiumello. Lung and diaphragm protective ventilation guided by the esophageal pressure. Intensive Care Med 2022;epublished July 29th
- Maciel. Urine biochemistry assessment in the sequential evaluation of renal function: Time to think outside the box. Front Med 2022;9:912877
- McLean. Transcriptomics in the intensive care unit. Intensive Care Med 2022;epublished July 22nd
Case Reports
- López-Brull. Ventilator integrated polygraphy for patients using non-invasive ventilation; Case report. Front Med 2022;9:852896
- Kopanczyk. Persistent Hypoxemia in COVID-19 Patients on ECMO: Keep Your Eyes on the Prize. J Cardiothor Vasc Anaesth 2022;36(9):3710-3711
- Nishikawa. Cardiogenic Shock Due to Unsuspected Tachycardia in a Child. JACC Case Rep 2022;4(14):885-889
- Abdullatheef. Tension Fecopneumothorax. J Emerg Trauma Shock 2022;15(2):105-107
I hope you find this newsletter useful.
Until the weekend
Rob
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