Critical Care Reviews Newsletter
Newsletter 592 | April 16th, 2023
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Less than 8 weeks to CCR23
Welcome to the 592nd Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.
The highlights of this week's edition are randomised controlled trials on delayed versus rapid sequence intubation in critically injured patients & higher dose corticosteroids in patients admitted to hospital with COVID-19 who are hypoxic but not requiring ventilatory support; systematic reviews and meta analyses on propofol and survival & atypical pathogens in patients with severe pneumonia; and observational studies on whole blood resuscitation and the association with survival in injured patients with an elevated probability of mortality & the risk of death in patients hospitalized for COVID-19 vs seasonal Influenza in Fall-Winter 2022-2023.
There are also guidelines on adult acute and acute-on-chronic liver failure & exertional heat illness; narrative reviews on monitoring cerebral oxygenation in non brain injured patients & medical nutrition therapy in critically ill patients; editorials on clinical practice guidelines for acute-on-chronic liver failure & α-Defensins to help diagnose nosocomial ventriculitis; and commentaries on peripheral nerve blockade in extremity trauma & intracranial compartmental syndrome.
If you only have time to read one review article this week, try this one on the management of pregnant trauma patients.
Critical Care Reviews Meeting 2023
There are now less than 8 weeks to CCR23. The full provisional programme should be out this week, in addition to the release of the one-day registration options. At present we have announced 6 major trial result presentations and 5 reviews of previously published trials. This week we'll add the final review talk, two panel discussions, the John Hinds lecture and, hopefully, squeeze in a seventh major trial result presentation. If you're interested in the trials which lay the foundations for clinical practice in critical care, this is the meeting for you. With less than 2 months to go, don't delay registering or you might miss out.
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Research
Randomised Controlled Trials
- Bandyopadhyay. Peri-Intubation Hypoxia After Delayed Versus Rapid Sequence Intubation in Critically Injured Patients on Arrival to Trauma Triage: A Randomized Controlled Trial. Anesth Analg 2023;136(5):913-919
- RECOVERY Collaborative Group. Higher dose corticosteroids in patients admitted to hospital with COVID-19 who are hypoxic but not requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial. Lancet 2023;epublished April 12th
- Writing Committee for the REMAP-CAP Investigators. Effect of Angiotensin-Converting Enzyme Inhibitor and Angiotensin Receptor Blocker Initiation on Organ Support-Free Days in Patients Hospitalized With COVID-19: A Randomized Clinical Trial. JAMA 2023;329(14):1183-1196
- Self. Renin-Angiotensin System Modulation With Synthetic Angiotensin (1-7) and Angiotensin II Type 1 Receptor-Biased Ligand in Adults With COVID-19: Two Randomized Clinical Trials. JAMA 2023;329(14):1170-1182
- Wang. The effectiveness of early surgical stabilization for multiple rib fractures: a multicenter randomized controlled trial. J Cardiothorac Surg 2023;18(1):118
Systematic Review & Meta Analyses
- Kotani. Propofol and survival: an updated meta-analysis of randomized clinical trials. Crit Care 2023;27(1):139
- Wang. Prevalence of atypical pathogens in patients with severe pneumonia: a systematic review and meta-analysis. BMJ Open 2023;13(4):e066721
Observational Studies
- Sperry. Whole Blood Resuscitation and Association with Survival in Injured Patients with an Elevated Probability of Mortality. J Am Coll Surg, April 11, 2023.
- Chen. A Large-Scale Multi-Center Retrospective Study on Nephrotoxicity Associated with Empiric Broad Spectrum Antibiotics in Critically Ill Patients. Chest, April 9, 2023.
- Jung. Arrhythmic Events and Mortality in Patients With Cardiogenic Shock on Inotropic Support: Results of the DOREMI Randomized Trial. Can J Cardiol, April 2023.
- Legriel. Outcomes in COVID-19 Patients With Acute Encephalopathy and Coma: An International Prospective Study. Neurology, April 11, 2023.
- Spinelli. Clinical risk factors for increased respiratory drive in intubated hypoxemic patients. Crit Care 2023;27:138
- Laws. Acute Effects of Ketamine on Intracranial Pressure in Children With Severe Traumatic Brain Injury. Crit Care Med 2023;51:563-572
- Ashton. Alzheimer Disease Blood Biomarkers in Patients With Out-of-Hospital Cardiac Arrest. JAMA Neurol 2023;80:388-396
- Xie. Risk of Death in Patients Hospitalized for COVID-19 vs Seasonal Influenza in Fall-Winter 2022-2023. JAMA 2023;epublished April 6th
Protocols
- Pickkers. Study protocol of a randomised, double-blind, placebo-controlled, two-arm parallel-group, multi-centre phase 3 pivotal trial to investigate the efficacy and safety of recombinant human alkaline phosphatase for treatment of patients with sepsis-associated acute kidney injury. BMJ Open. 2023 Apr 3;13(4):e065613.
- David. EXCHANGE-2: investigating the efficacy of add-on plasma exchange as an adjunctive strategy against septic shock-a study protocol for a randomized, prospective, multicenter, open-label, controlled, parallel-group trial. Trials. 2023 Apr 15;24(1):277.
- Ripoll. Liver-HERO: hepatorenal syndrome-acute kidney injury (HRS-AKI) treatment with transjugular intrahepatic portosystemic shunt in patients with cirrhosis—a randomized controlled trial. Trials 24, 258 (2023).
- Yuan. Effect of EIT-guided PEEP titration on prognosis of patients with moderate to severe ARDS: study protocol for a multicenter randomized controlled trial. Trials 2023;24:266.
- Bosma. Study protocol for a randomized controlled trial of Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation: the PROMIZING study. Trials 2023;24:232
Guidelines
- Guidelines for the Management of Adult Acute and Acute-on-Chronic Liver Failure in the ICU: Neurology, Peri-Transplant Medicine, Infectious Disease, and Gastroenterology Considerations
- ACSM Expert Consensus Statement on Exertional Heat Illness: Recognition, Management, and Return to Activity. Armstrong LE. Curr Sports Med Rep 2023;22(4):134-149
Reviews
Clinical
COVID-19
- Mallat. Is COVID-19 different from other causes of acute respiratory distress syndrome? J Intensive Med 2023;epublished April 11th
- Management of Coronavirus Disease-2019 Infection in Pregnancy. Herrera. Emerg Med Clin North Am 2023;41(2):307-322
Neurological
- Robba. The Importance of Monitoring Cerebral Oxygenation in Non Brain Injured Patients. J Clin Monit Comput 2023;epublished April 12th
- McMahon. Commonly encountered central nervous system infections in the intensive care unit. BJA Education 2023;epublished April 11th
- De Laco. Managing emergency and urgent care in spinal muscular atrophy. Ital J Emerg Med 2023;12(1):4-8
- Barkas. A step-by-step guide for the diagnosis and management of hyponatraemia in patients with stroke. Ther Adv Endocrinol Metab 2023;epublished April 3rd
Circulatory
Respiratory
Gastrointestinal
Nutrition
Hepatobiliary
- Jung. Hepatorenal Syndrome: Current Concepts and Future Perspectives. Clin Mol Hepatol 2023;epublished April 13th
- Kumar. Acute-on-Chronic Liver Failure – Terminology, Mechanisms and Management. Clin Mol Hepatol 2023;epublished February 25th
- Dirchwolf. Challenges and recommendations when selecting empirical antibiotics in patients with cirrhosis. World J Hepatol 2023;15(3):377-385
Renal
- Rodrigues. Definitions, phenotypes, and subphenotypes in acute kidney injury—Moving towards precision medicine. Nephrology 2023;28(2):83-96
- Al Sahlawi. Peritoneal Dialysis in Critically Ill Patients Time for a Critical Reevaluation? Clin J Am Soc Nephrol 2023;18(4):512-520
Haematological
Sepsis
Trauma
- Crowley. Current practice in the perioperative management of patients with diabetes mellitus: a narrative review. Br J Anaesth 2023;epublished April 13th
- Blaine. Training Anesthesiology Residents to Care for the Traumatically Injured in the United States. Anesth Analg 2023;136(5):861-876
Obstetrics
Perioperative
Non-Clinical
Editorials
- Juffermans. ICM experimental is growing, from bench via bedside to big data-and back! Intensive Care Med Exp 2023;11(1):24
- Doub. Use of α-Defensins to Help Diagnose Nosocomial Ventriculitis. Neurocrit Care 2023;38:225-228
- Engelmann. Clinical practice guidelines for acute-on-chronic liver failure: are we ready for reaching global consensus? HepatoBiliary Surg Nutr 2023;12(2):239-243
Commentaries
- Kupersmith. Specific recommendations to improve the design and conduct of clinical trials. Trials 2023;24:263
- Morgan. ICU's most powerful tool will always be skilled staff. BMJ 2023;381:p804
- Grewal. Tumour lysis syndrome. CMAJ 2023;195(14):E515
- Lee. A humanitarian’s perspective of critical care in conflict zones. Intensive Care Med 2023;epublished April 12th
- Samet. Pro-Con Debate: Peripheral Nerve Blockade Should Be Provided Routinely in Extremity Trauma, Including in Patients At Risk for Acute Compartment Syndrome. Anesth Analg 2023;136(5):855-860
- Godoy. The intracranial compartmental syndrome: a proposed model for acute brain injury monitoring and management. Crit Care 2023;27(1):137
- Checcucci. Generative Pre-training Transformer Chat (ChatGPT) in the scientific community: the train has left the station. Minerva Urol Nefrol 2023;75(2):131-3
Correspondence
- Porter. Different perspectives of ethical climate and collaboration between ICU physicians and nurses. Intensive Care Med 2023;epublished April 8th
- Cai. Erector spinae plane block: inexplicable benefits in acute gastrointestinal injury. Author's reply. Intensive Care Med 2023;epublished April 5th
- Guervilly. Determinants of long-term outcomes in patients with COVID-19 supported with ECMO. Lancet Respir Med 2023;epublished April 5th
Case Reports
- Yi. Intracardiac Echogenicity During Cardiopulmonary Bypass in a Vasoplegic Patient undergoing Coronary Artery Bypass Grafting: To Explore or To Ignore. J Cardiothorac Vasc Anesth 2022;epublished December 26th
- Morrison-Nozik. Airway management in a patient with Stevens-Johnson syndrome/toxic epidermal necrolysis: a case report. J Head Neck Anesth 2022;6(2):e42
- Yamamoto. Blow-out left ventricular free wall rapture. Eur Heart J Case Reports 2022;6(12):ytac456
- Xie. A huge right atrial synovial sarcoma originating from the Koch triangle causing a third-degree atrioventricular block. Intensive Care Med 2022;epublished December 22nd
- Haddad. Acute pancreatitis secondary to hypercalcemia in a patient with primary hyperparathyroidism: An uncommon association. Ann Med Surg 2022;84:104832
I hope you find this newsletter useful.
Until next week
Rob