Just 6 Weeks to CCR23 - The Best Critical Care Trials in the World
Welcome to the 594th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.
The highlights of this week's edition are randomised controlled trials comparing decompressive craniectomy with craniotomy for acute subdural hematoma & high vs. low mean arterial pressure in patients with cirrhosis and septic shock; systematic reviews and meta analyses on the clinical impact of the pulmonary artery catheter in patients with cardiogenic shock & glutamine supplementation in severe adult burn patients; and observational studies on lung recruitment assessed by electrical impedance tomography & the determinants of effect of extracorporeal CO2 removal in hypoxemic respiratory failure.
There are also guidelines & position statements on new timings in acute care surgery (new TACS) classification & the role of natriuretic peptides in the diagnosis and management of heart failure; narrative reviews on the differential diagnosis and treatment of acute heart failure & the use of hypertonic saline in neuroanesthesia and neurocritical care practice; editorials on familiarity among nurses: the key to ICU patient outcomes & "stabilize the unstable": treatment pathophysiology in bleeding trauma patients; and commentaries on the optimal management of patients after acute coronary syndrome & fluid removal tolerance during the de-escalation phase: is preload unresponsiveness the best guiding candidate?.
If you only have time to read one review article this week, try this one on ultrasonography in cardiopulmonary emergencies.
Critical Care Reviews Meeting 2023
The provisional programme for CCR23 is now available. Our faculty continues to grow, with the latest updates on the faculty webpage. If you intend to reserve a place at our professional childminding, please get in touch as this will close in the next couple of weeks.
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Research
Randomised Controlled Trials
- Hutchinson. Decompressive Craniectomy versus Craniotomy for Acute Subdural Hematoma. N Engl J Med 2023;epublished April 23rd
- Maiwall et al. A randomized-controlled trial (TARGET-C) of high vs. low target mean arterial pressure in patients with cirrhosis and septic shock. J Hepatol 2023;epublished April 21st
- Salton. Prolonged higher dose methylprednisolone versus conventional dexamethasone in COVID-19 pneumonia: a randomised controlled trial (MEDEAS). Eur Respir J 2023;61(4)
- Carrié. Hypotension-Avoidance Versus Hypertension-Avoidance Strategies in Noncardiac Surgery: An International Randomized Controlled Trial. Ann Intern Med 2023;epublished April 25th
- Rieu. Early non-invasive ventilation and high-flow nasal oxygen therapy for preventing endotracheal intubation in hypoxemic blunt chest trauma patients: the OptiTHO randomized trial. Crit Care 2023;27:163
- Piccioni. One-lung ventilation and postoperative pulmonary complications after major lung resection surgery: A multicenter randomized controlled trial. J Cardiothorac Vasc Anesth 2023;epublished April 26th
- Louie. VE303, a Defined Bacterial Consortium, for Prevention of Recurrent Clostridioides difficile Infection: A Randomized Clinical Trial. JAMA 2023;329(16)
- Hu. Safety, tolerability, pharmacokinetics, and efficacy of kukoamine B in patients with sepsis: A randomized phase IIa trial. J Crit Care 2023;76:154294
Systematic Review & Meta Analyses
- Covello. Meta-Analysis of Glucocorticoids for Covid-19 Patients Not Receiving Oxygen. NEJM Evid 2023;2(5)
- Yoo. Clinical impact of pulmonary artery catheter in patients with cardiogenic shock: A systematic review and meta-analysis. Cardiovasc Revasc Med 2023
- Wu. Effects of different types and frequencies of early rehabilitation on ventilator weaning among patients in intensive care units: A systematic review and meta-analysis. PLoS One 2023;18(4)
- Lee. Survival Benefits of Therapeutic Plasma Exchane in Severe Sepsis and Septic Shock: A Systematic Review and Meta-analysis. J Intensive Care Med 2023
- Ortiz-Reyes. The Efficacy of Glutamine Supplementation in Severe Adult Burn Patients: A Systematic Review With Trial Sequential Meta-Analysis. Crit Care Med 2023
- Song. Association of Dexmedetomidine With New-Onset Atrial Fibrillation in Patients With Critical Illness. JAMA Netw Open 2023;6(4)
- Kotani. Etomidate as an induction agent for endotracheal intubation in critically ill patients: A meta-analysis of randomized trials. J Crit Care 2023;77:154317
- Goel. Early versus deferred coronary angiography following cardiac arrest. A systematic review and meta-analysis. Resusc Plus 2023;14:100381
Observational Studies
- Jonkman. Lung RecruitmEnt Assessed by EleCtRical Impedance Tomography (RECRUIT): A Multicenter Study of COVID-19 ARDS. Am J Respir Crit Care Med 2023;epublished Apilr 25th
- Dianti. Determinants of Effect of Extracorporeal CO2 Removal in Hypoxemic Respiratory Failure. NEJM Evid 2023;2(5)
- Russo. Efficacy of cefiderocol- versus colistin-containing regimen for treatment of bacteremic ventilator-associated pneumonia caused by carbapenem-resistant Acinetobacter baumannii in COVID-19 patients. Int J Antimicrob Agents 2023;epublished April 21st
- Mathis. Patient-, Clinician-, and Institution-level Variation in Inotrope Use for Cardiac Surgery: A Multicenter Observational Analysis. Anesthesiology 2023;epublished April 24th
- Thau. Association of Trauma Molecular Endotypes With Differential Response to Transfusion Resuscitation Strategies. JAMA Surg 2023;epublished April 26th
- Zampieri. Attributable mortality due to nosocomial sepsis in Brazilian hospitals: a case–control study. Ann Intensive Care 2023;13:32
- Wang. Emulation of Randomized Clinical Trials With Nonrandomized Database Analyses: Results of 32 Clinical Trials. JAMA. 2023;329(16):1376-1385
- Bermejo-Martin. Effect of viral storm in patients admitted to intensive care units with severe COVID-19 in Spain: a multicentre, prospective, cohort study. Lancet Microbe 2023;epublished April 25th
- Dionne. Clostridioides difficile infection in mechanically ventilated critically ill patients: A nested cohort study. J Crit Care 2023;75:154254
Protocols
Guidelines
- Management of vagus nerve simulation therapy in the peri-operative period: Guidelines from the Association of Anaesthetists. Anaesthesia 2023;epublished Apr 25th
- Natriuretic Peptides: Role in the Diagnosis and Management of Heart Failure: A Scientific Statement From the Heart Failure Association of the European Society of Cardiology, Heart Failure Society of America and Japanese Heart Failure Society. Eur J Heart Fail 2023;epublished April 26th
- The new timing in acute care surgery (new TACS) classification: a WSES Delphi consensus study. World J Emerg Surg 2023;18:32
- Fragkou. Update of ESCMID COVID-19 guidelines: diagnostic testing for SARS-CoV-2. Clin Microbiol Infect 2023;epublished April 21st
Reviews
Clinical
COVID-19
- Mazzon. The SARS-CoV-2 pandemic as a source of unprecedented bioethical and biolaw issues: lessons for intensivists. J Anesth Analg Crit Care 2023;3:8
- Kiss. Management of the Normal and Difficult Pediatric Airway: Unique Challenges in the Time of COVID-19. Curr Surg Rep 2023;11:144–153
- Edinoff. Tocilizumab for Severe COVID-19 Infection and Multisystem Inflammatory Syndrome in Adults and Children. Life 2023;13(4):889
Neurological
- Claytor. Myasthenic crisis. Muscle Nerve 2023;epublished April 28th
- Barik . Use of Hypertonic Saline in Neuroanesthesia and Neurocritical Care Practice: A Narrative Review. J Neuroanaesth Crit Care 2023;epublished April 24th
- Samagh. Post-craniotomy Pain: An Update. J Neuroanaesth Crit Care 2023;epublished April 24th
Circulatory
- Marini. Acute heart failure: differential diagnosis and treatment. Eur Heart J 2023;22(Suppl 25):C276–C282
- Abdul-Rahman. The Use of Cardioprotective Devices and Strategies in Patients Undergoing Percutaneous Procedures and Cardiac Surgery. Healthcare 2023;11(8):1094
- Herrera-Hidalgo. Treatment of Enterococcus faecalis Infective Endocarditis: A Continuing Challenge. Antibiotics 2023;12(4):704
Resuscitation
Respiratory
- Gattinoni. Prone position: how understanding and clinical application of a technique progress with time. APS 2023;1(1):3
- Sklienka. Patient Self-Inflicted Lung Injury-A Narrative Review of Pathophysiology, Early Recognition, and Management Options. J Pers Med 2023;13(4):593
- Liang. Current status and prospects of basic research and clinical application of mesenchymal stem cells in acute respiratory distress syndrome. World J Stem Cells 2023;15(4):150-164
- Qiu. Research Progress of the Association of the Neutrophil Elastase with Sepsis-related Acute Lung Injury. J Transl Crit Care Med 2023;5:e00008
Nutrition
Endocrine
- Sreedharan. Perioperative glycemic management in adults presenting for elective cardiac and non-cardiac surgery. Perioper Med 2023;12(1):13
- Melendo-Viu. Left Ventricular Assist Device as a Destination Therapy: Current Situation and the Importance of Patient Selection. Life 2023;13(4):1065
Metabolic
Sepsis
- Novy. The Current Status and Future Perspectives of Beta-Lactam Therapeutic Drug Monitoring in Critically Ill Patients. Antibiotics 2023;12(4):681
- Karvouniaris. Novel Antimicrobial Agents for Gram-Negative Pathogens. Antibiotics 2023;12:(4)761
- Boyer. Treatment of Invasive Aspergillosis: How It’s Going, Where It’s Heading. Mycopathologia 2023;epublished April 26th
- Esposito. New Antibiotics for Staphylococcus aureus Infection: An Update from the World Association of Infectious Diseases and Immunological Disorders (WAidid) and the Italian Society of Anti-Infective Therapy (SITA). Antibiotics 2023;12(4):742
- Codelia-Anjum. Enterococcal Urinary Tract Infections: A Review of the Pathogenicity, Epidemiology, and Treatment. Antibiotics 2023;12(4):778
- Diallo. A Century of Clinical Use of Phages: A Literature Review. Antibiotics 2023;12(4):751
Paediatrics
- Operationalizing Appropriate Sepsis Definitions in Children Worldwide: Considerations for the Pediatric Sepsis Definition Taskforce. Crit Care Med 2023;epublished April 25th
- Yamamoto, Schindler. Regional anesthesia as part of enhanced recovery strategies in pediatric cardiac surgery. Curr Opin Anaesthesiol 2023;36(3):324-333
Imaging
- Bos. Radiation Exposure in Computed Tomography. Dtsch Arztebl Int 2023;120:135-41
- Clevert. Ultrasound—New Techniques Are Extending the Applications. Dtsch Arztebl Int 2023; 120:41-7
Artificial Intelligence
- Wardi. Bringing the Promise of Artificial Intelligence to Critical Care: What the Experience With Sepsis Analytics Can Teach Us. Crit Care Med 2023;epublished April 26th
- Brownstein. Advances in Artificial Intelligence for Infectious-Disease Surveillance. N Engl J Med 2023; 388:1597-1607
Miscellaneous
Pre-Clinical
- Zanza. Severe Trauma-Induced Coagulopathy: Molecular Mechanisms Underlying Critical Illness. Int J Mol Sci. 2023 Apr 12;24(8):7118
- Garduno. Multi-Omics Endotypes in ICU Sepsis-Induced Immunosuppression. Microorganisms 2023;11:1119
Veterinary
Editorials
- Ratliff. Familiarity Among Nurses: The Key to ICU Patient Outcomes? Am J Respir Crit Care Med 2023;207(8):966-967
- Olasveengen. Prehospital ventilation targets in severe traumatic brain injury. Intensive Care Med. 2023;epublished April 15th
- Bini. "Stabilize the Unstable": Treatment Pathophysiology in Bleeding Trauma Patients, from the Field to the ICU. State of the Art. J Pers Med 2023;13(4):667
Commentaries
- Gaita. Atrial fibrillation fundamentals: from physiopathology to transcatheter ablation. Eur Heart J 2023;25(Suppl C):C7–C11.
- Capucci. Anti-arrhythmic drugs in atrial fibrillation: tailor-made treatments. Eur Heart J 2023;25(Suppl C):C12–C14
- De Marco. Management of bleeding in patients on direct oral anticoagulants in emergency department: where we are and where we are going. Eur Heart J 2023;25(Suppl C):C15–C19
- Giustetto. The Brugada syndrome: pharmacological therapy. Eur Heart J Suppl 2023;25(Suppl_C):C32-C37
- Maragna. Cardiac computed tomography: from anatomy to function. Eur Heart J Suppl 2023;25(Suppl_C):C49-C57
- Scatteia. Cardiac magnetic resonance in ischemic cardiomyopathy: present role and future directions. Eur Heart J Suppl 2023;25(Suppl_C):C58-C62
- Picano. Stress Echo 2030: the new ABCDE protocol defining the future of cardiac imaging. Eur Heart J Suppl 2023;25(Suppl_C):C63-C
- Zimbardo. Acute coronary syndromes and multivessel coronary artery disease. Eur Heart J Suppl 2023;25(Suppl_C):C74-C78
- Panattoni. Optimal management of patients after acute coronary syndrome. Eur Heart J Suppl 2023;25(Suppl_C):C84-C89
- Leone. Acute coronary complications in chronic total occlusion interventions. Eur Heart J Suppl 2023;25(Suppl_C):C96-C105
- Schiavone. Cardiac resynchronization therapy: present and future. Eur Heart J Suppl 2023;25(Suppl_C):C227-C233
- Dusi. Electrical storm management in structural heart disease. Eur Heart J Suppl 2023;25(Supplement_C):C242–C248
- Parlati. Management of heart failure: similarities and discrepancies between the European Society of Cardiology and the American Heart Association guidelines. Eur Heart J Suppl 2023;25(Supplement_C):C271–C275
- Marini. Acute heart failure: differential diagnosis and treatment. Eur Heart J Suppl 2023;25(Supplement_C):C276–C282
- Garascia. Advanced heart failure: from definitions to therapeutic options. Eur Heart J Suppl 2023;25(Supplement_C):C283–C291
- D'Andrea. Multimodality imaging in decompensated heart failure. Eur Heart J Suppl 2023;25(Supplement_C):C292–C300
- Monzo. Sodium-glucose co-transporter 2 inhibitors in heart failure: an updated evidence-based practical guidance for clinicians. Eur Heart J Suppl 2023;25(Supplement_C):C309–C315
- Li., Perspective from anesthesiologists on the therapy of critically ill patients with COVID-19. APS 2023;1:5
- Ruste. Fluid removal tolerance during the de-escalation phase: is preload unresponsiveness the best guiding candidate? Crit Care 2023;27(1):154
- Maesaka., Cerebral Salt Wasting Is a Real Cause of Hyponatremia: PRO. Kidney360 2023;4(4):e437-e440
- Sterns, Cerebral Salt Wasting Is a Real Cause of Hyponatremia: CON. Kidney360 2023;4(4):e441-e444
- Wolinetz., Transforming Clinical Research to Meet Health Challenges. JAMA 2023;epublished April 28th
- Muscente. The new in anticoagulation: factor XI inhibitors. Eur Heart J Suppl. 2023;25(Supplement_B):B65-B68
- De Gaspari. Causes of sudden death. Eur Heart J Suppl. 2023;25(Supplement_B):B16-B20
- Pepi. Challenges in cardiology: diagnosis of native and prosthetic valve endocarditis. Eur Heart J Suppl. 2023;25(Supplement_B):B131-B135
- Balestrieri. Heart failure therapy: the fifth card. Eur Heart J Suppl. 2023;25(Supplement_B):B140-B143
- Tarasi. Nightmare in the ward: difficult Clostridioides infection. Eur Heart J Suppl. 2023;25(Supplement_B):B161-B165
- Verdecchia. Therapy of Type 2 diabetes: more gliflozines and less metformin? Eur Heart J Suppl. 2023;25(Supplement_B):B171-B176
Correspondence
- Fukano. Assessment of selective coronary perfusion using transesophageal echocardiography. J Cardiothorac Vasc Anesth 2023;epublished April 24th
- Hayanga. The Anesthesiologist's Role in ECMO for COVID-19: Cannulate Extubate Ambulate: The Anesthesiologist's Role in Rapid Deployment of Extracorporeal Support During the COVID-19 Pandemic. J Cardiothorac Vasc Anesth 2023;epublished April 27th
- Smit. Reply to: Quantify or Diagnose ARDS by Lung Ultrasound. Am J Respir Crit Care Med. 2023;epublished April 26th
Case Reports
I hope you find this newsletter useful.
Until next week
Rob