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Would you like to receive the latest critical care literature every weekend?
Get the Critical Care Reviews Newsletter - there's nothing else like it!
Latest Randomised Trials
- Sankar. Vitamin C Versus Placebo in Pediatric Septic Shock (VITACiPS) - A Randomised Controlled Trial. J Intensive Care Med 2025;epublished July 24th
- Miggelbrink. Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in the perioperative period: withdraw or continue? A multicentre randomised controlled trial. Br J Anaesth 2025;epublished July 22nd
- Pradeep Babu. Sedative and analgesic drug rotation protocol versus non-rotation protocol in mechanically ventilated children: A randomised controlled trial. Indian J Pediatr 2025;epublished March 5th
- Abogabal. Sevoflurane sedation as an alternative for awake fiberoptic intubation in difficult airway patients: a randomized controlled trial. Minerva Anestesiol 2025;epublished July 21st
Last updated July 26th
Latest Meta Analyses
- Abdollahifard. Timing of Intracranial Pressure Monitoring in Traumatic Brain Injury: A Systematic Review and Meta-Analysis. World Neurosurg 2025;199:124136
- Pazo-Palacios. Effects of in-bed cycling in critically ill adults: A systematic review and meta-analysis of randomised clinical trials. Ann Phys Rehabil Med 2025;68(5):101953
- Romantsik. Midazolam for sedation of infants in the neonatal intensive care unit. Cochrane Database Syst Rev 2025;7(7):CD002052
- Leong. A systematic review and meta-analysis of noradrenaline compared to adrenaline in the management of septic shock. Afr J Emerg Med 2025;15(3):100881
- Tang. Melatonin Use in the ICU: A Systematic Review and Meta-Analysis. Crit Care Med 2025;epublished July 15th
- Jiang. Factors Influencing Quality of Life After Intensive Care: A Systematic Review and Meta-Analysis. Crit Care Med 2025;epublished July 15th
Last updated July 24th
Latest Observational Studies
- Telias. Physiological Consequences of Breathing Effort According to the Mode of Ventilation During Acute Hypoxemic Respiratory Failure. Am J Respir Crit Care Med 2025;epublished July 23rd
- Song. Association between the Venous Excess Ultrasound (VExUS) score and acute kidney injury in critically ill patients with sepsis: a multicenter prospective observational study. Ann. Intensive Care 2025;15:105
- Heydari. The role of serial point-of-care ultrasound during cardiac arrest to predict termination of resuscitation. Scand J Trauma Resusc Emerg Med 2025;33:129
- McBride. Temporal Patterns in Out-of-Hospital Cardiac Arrest Incidence and Outcome. JAMA Cardiol 2025;epublished July 16th
- Bernhardt. Timing of trauma deaths due to uncontrolled bleeding have not changed in three decades: A multicenter study of patients in hemorrhagic shock. Am J Surg 2025;:250:116510
Last updated July 26th
Latest Guidelines
- Use of extracorporeal membrane oxygenation in adult trauma patients with refractory acute cardiopulmonary failure: guideline from the Chinese society of extracorporeal life support 2025. Crit Care 2025;29:334
- Godwin. Clinical Policy: Critical Issues in the Management of Adult Patients Requiring Endotracheal Intubation in the Emergency Department. Ann Emerg Med 2025;86(2):e29-e68
- Borland. Australasian Bronchiolitis Guideline: 2025 Update. J Paediatr Child Health 2025;epublished Jul 20th
- Diagnosis and Management of Community-acquired Pneumonia. An Official American Thoracic Society Clinical Practice Guideline. Am J Respir Crit Care Med 2025;epublished July 18th
Last updated July 31st
Latest Narrative Reviews
- Gerard. Is "pre-sepsis" the new sepsis? A narrative review. PLoS Pathog 2025;21(7):e1013372
- Varrassi. Timely interventions for better outcomes in cardiac emergencies: a narrative review. Signa Vitae 2025,21(7):16-28
- Palmer. Mixed Acid-Base Disturbances: Core Curriculum 2025. Am J Kidney Dis 2025;epublished July 29th
- Lajoye. Vasopressin and its analogues in patients with septic shock: holy Grail or unfulfilled promise?. Crit Care 2025;29:333
- D’Andria Ursoleo. Norepinephrine pharmacolexicology: a chronological review of dose reporting and the implications of salt formulations. Intensive Care Med 2025;epublished July 29th
Last updated August 1st
Latest Editorials
- van Regenmortel. Maintenance and resuscitation fluids for brain injury: keep them salty and not too sweet but mind the kidney. Intensive Care Med 2025;epublished July 29th
- Conway Morris. Syndromic diagnostics in pneumonia: the quest for impact continues. Intensive Care Med 2025;epublished July 28th
- Montgomery. Climate change impacts: survival on, and of, intensive care. Crit Care 2025;29:335
- Nasa. Defining the Acute Respiratory Distress Syndrome - Are You a Splitter or a Lumper? The Choice Matters more than You Think. Indian J Crit Care Med 2025;29(7):551-553
Last updated July 31st
Latest Commentaries
- Hahn. Choosing wisely: who really benefits from critical care EEG monitoring?. Intensive Care Med 2025;epublished July 28th
- McLean. Rinaldo Bellomo – An Intensive Care Medicine Icon. Crit Care 2025;29:319
- Deana. Muscle mass evaluation at lumbar level in ICU patients: a call for collaborative approach between intensivists and radiologists. Crit Care 2025;29:317
- Swain. Unplanned intensive care unit admissions in trauma patients: A critical appraisal. World J Crit Care Med 2025;14(3):105147
- Chervenkov. Utilizing artificial intelligence as an arbitrary tool in managing difficult COVID-19 cases in critical care medicine. World J Crit Care Med 2025;14(3):102808
Last updated July 31st
CCR Down Under 2025

Registration has opened for CCR Down Under in Melbourne, on December 9th and 10th, again at the Edge in Federation Square.
We aim to bring another set of fantastic international critical care trials to Australia. If you are interested in the science underlying clinical practice, this is the meeting for you.
We're delighted to be partnering once again with the Alfred Intensive Care Academic Centre, and this year, with Monash University.
If you missed the presentations last December, the presentations of the so far published trials are available here.



CCR Content

Paper of the Day
Friday, August 1st
Join us to read one paper per day and cover the spectrum of critical care across 2025. Previous papers of the day are available here.

Newsletter 711
Critical Care Reviews Newsletter 711, bringing you the best critical care research and open access articles for the week July 21st to 27th.
Subscriptions are available to individuals and departments.
added July 29th

Foundational Trials
We start a new section looking at the foundation trials in critical care and start with probably the most important trial yet in the field.
added July 15th

Highlighted Narrative Reviews
With thousands of open access narrative reviews listed across the website, CCR provides a comprehensive educational resource. We'll highlight one topic here every few days. Today, we look at Acute Kidney Injury
added July 15th

Highlighted Guidelines
Need a guideline, or just want to refresh your knowledge on the evidence-based management of a particular condition? We provide more up-to-date guidelines than any other critical care resource. have a look at our Burns guideline section
added July 13th
CCR Meeting Talks
After 14 meetings, we have a huge collection of superb presentations. We'll showcase them here, one at a time.
CCR24
The PRE-OXI Trial Results
Jonathan Casey and Kevin Gibbs present the results of the PRE-OXI trial at the Critical Care Reviews Meeting 2024, in Titanic Belfast. PRE-OXI investigated non-invasive ventilation for preoxygenation in emergency intubation in the critically ill.
Yonathan Freund delivers an independent editorial. Catriona Kelly chairs a panel discussion with Anthony Gordon, Sheila Myatra, Victoria Cornelius and Jan Gunst.
PRE-OXI was simultaneously published in the New England Journal of Medicine.
added July 21st