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- de Mesmay. Effect of paracetamol on cerebral temperature in febrile brain-injured patients.The NEUROTHERM study:a randomized controlled pharmacodynamic trial.Crit Care Med 2025;epublished November 11th
- Godet. Dexmedetomidine for treatment of hyperactive delirium in non-intubated ICU patients: the 4D randomized clinical trial. Intensive Care Med 2025;epublished October 30th
- Khan. Slow-tempo music and delirium/coma-free days among older adults undergoing mechanical ventilation: a randomized clinical trial. JAMA Intern Med 2025;epublished Oct 13th
- Writing Committee for the PEARL Investigators. Intra-arterial alteplase after successful endovascular reperfusion in acute stroke: the PEARL randomized clinical trial. JAMA 2025;epublished Oct 13th
- Miao. Intra-arterial Tenecteplase for Acute Stroke After Successful Endovascular Therapy: The ANGEL-TNK Randomized Clinical Trial. JAMA 2025;epublished July 5th
- Tao. Early Tirofiban Infusion after Intravenous Thrombolysis for Stroke. N Engl J Med 2025;epublished July 3rd
- Mekontso Dessap. Melatonin for prevention of delirium in patients receiving mechanical ventilation in the intensive care unit: a multiarm multistage adaptive randomized controlled clinical trial (DEMEL). Intensive Care Med 2025;epublished July 3rd
- Jabaudon. Inhaled Sedation in Acute Respiratory Distress SyndromeThe SESAR Randomized Clinical Trial. JAMA 2025;epublished March 18th
Observational Study
- Combes. Levosimendan to facilitate weaning from ECMO in patients with severe cardiogenic shock: the LEVOECMO randomized clinical trial. JAMA 2025;epublished December 1st
- van’t Hof. Zalunfiban at first medical contact for ST-elevation myocardial infarction.N Engl J Med Evid 2025;epublished November 10th
- Lookstein. Randomized Controlled Trial of Mechanical Thrombectomy With Anticoagulation Versus Anticoagulation Alone for Acute Intermediate-High Risk Pulmonary Embolism: Primary Outcomes from the STORM-PE Trial. Circulation 2025;epublished November 3rd
- Muller. Deferring Arterial Catheterization in Critically Ill Patients with Shock. N Engl J Med 2025; epublished October 29th
- Nijveldt. Immediate or deferred nonculprit-lesion PCI in myocardial infarction. N Engl J Med 2025;epublished October 28th
- McIntyre. A Crossover Trial of Hospital-Wide Lactated Ringer’s Solution versus Normal Saline. NEJM 2025;epublished June 12th
- Endo. Efficacy of targeting high mean arterial pressure for older patients with septic shock (OPTPRESS): a multicentre, pragmatic, open-label, randomised controlled trial. Intensive Care Med 2025;epublished May 13th
- Morici. Early Intra-Aortic Balloon Support for Heart Failure-Related Cardiogenic Shock: A Randomized Clinical Trial. JACC 2025;epublished March 30th
- Casey. Ketamine or Etomidate for Tracheal Intubation of Critically Ill Adults. N Engl J Med 2025;epublished December 9th
- Treggiari. Hospital and long-term outcomes for subglottic suction and polyurethane cuff versus standard endotracheal tubes in emergency intubation (PreVent 2): a randomised controlled phase 2 trial. Lancet Respir Med 2025;epublished November 27th
- Sinnige. Effect of Automated Closed-Loop Ventilation vs Protocolized Conventional Ventilation on Ventilator-Free Days in Critically Ill Adults. A Randomized Clinical Trial. JAMA 2025;epublished December 8th
- Lemiale. Adjunctive corticosteroids in non-AIDS patients with severe Pneumocystis jirovecii pneumonia (PIC): a multicentre, double-blind, randomised controlled trial. Lancet Respir Med 2025;epublished July 10th
- Bosma. Proportional-Assist Ventilation for Minimizing the Duration of Mechanical Ventilation. N Engl J Med 2025;epublished June 13th
- Martin. Conservative Oxygen Therapy in Mechanically Ventilated Critically Ill Adult PatientsThe UK-ROX Randomized Clinical Trial. JAMA 2025;epublished June 12th
- Dres. Temporary Transvenous Diaphragm Neurostimulation for Weaning from Mechanical Ventilation (RESCUE-3). Am J Respir Crit Care Med 2025;epublished June 11th
- Monti. Early noninvasive ventilation in general wards for acute respiratory failure: an international, multicentre, open-label, randomised trial. Br J Anaesth 2024;epublished January 2nd
- Zarbock. A preventive care strategy to reduce moderate or severe acute kidney injury after major surgery (BigpAK-2): a multinational, randomised clinical trial. Lancet 2025;406(10521):2782-2791
- Liu. A conservative dialysis strategy and kidney function recovery in dialysis-requiring acute kidney injury: the Liberation From Acute Dialysis (LIBERATE-D) randomized clinical trial. JAMA 2025;epublished November 7th
- Jung. Sodium Bicarbonate for Severe Metabolic Acidemia and Acute Kidney Injury—the BICARICU-2 Randomized Clinical Trial. JAMA 2025; epublished October 29th
- Reade. Cryopreserved vs Liquid-Stored Platelets for the Treatment of Surgical Bleeding. The CLIP-II Randomized Noninferiority Clinical Trial. JAMA 2025;epublished December 8th
- Weitz. Efficacy and safety of REGN9933A2 and REGN7508Cat for preventing postoperative venous thromboembolism (ROXI-VTE-I and ROXI-VTE-II): two randomised, open-label, phase 2 trials. Lancet 2025;epublished November 8th
- Kougias. Liberal or restrictive postoperative transfusion in patients at high cardiac risk: the TOP randomized clinical trial. JAMA 2025;epublished November 8th
- Giamarellos-Bourboulis. Precision Immunotherapy to Improve Sepsis OutcomesThe ImmunoSep Randomized Clinical Trial. JAMA 2025;epublished December 8th
- ANDROMEDA-SHOCK-2 Investigators. Personalized Hemodynamic Resuscitation Targeting Capillary Refill Time in Early Septic Shock—the ANDROMEDA-SHOCK-2 Randomized Clinical Trial. JAMA 2025; epublished October 29th
- Lucinde. A Pragmatic Trial of Glucocorticoids for Community-Acquired Pneumonia. N Engl J Med 2025; epublished October 29th
- Tongyoo. Adjunctive terlipressin versus placebo in the treatment of refractory septic shock: a randomized, placebo-controlled trial. Crit Care 2025;29(1):443
- Pettilä. Targeted Tissue Perfusion Versus Macrocirculatory-Guided Standard Care in Patients With Septic Shock: A Randomized Clinical Trial-The TARTARE-2S Trial. Crit Care Med 2025;epublished October 17th
- Turner. Dalbavancin for treatment of Staphylococcus aureus bacteremia: the DOTS randomized clinical trial. JAMA 2025;epublished August 13th
- Voiriot. Combined use of a multiplex PCR and serum procalcitonin to reduce antibiotic exposure in critically ill patients with community-acquired pneumonia: the MULTI-CAP randomized controlled trial. Intensive Care Med 2025;epublished July 15th
- Derde. Tocilizumab, sarilumab and anakinra in critically ill patients with COVID-19: a randomised, controlled, open-label, adaptive platform trial. Thorax 2025;epublished May 13th
- The REMAP-CAP Investigators. Effect of hydrocortisone on mortality in patients with severe community-acquired pneumonia. Intensive Care Med 2025;epublished April 22nd
- Wu. The efficacy and safety of thymosin α1 for sepsis (TESTS): multicentre, double blinded, randomised, placebo controlled, phase 3 trial. BMJ 2025;388:e082583
- Burstein. Prediction of Bacteremia and Bacterial Meningitis Among Febrile Infants Aged 28 Days or Younger. JAMA 2025;epublished December 8th
- Oei. Targeted Oxygen for Initial Resuscitation of Preterm InfantsThe TORPIDO 30/60 Randomized Clinical Trial. JAMA 2025;epublished December 10th
- Sankar. Vitamin C Versus Placebo in Pediatric Septic Shock (VITACiPS) - A Randomised Controlled Trial. J Intensive Care Med 2025;epublished July 24th
- Miatello. Inhaled isoflurane for sedation of mechanically ventilated children in intensive care (IsoCOMFORT): a multicentre, randomised, active-control, assessor-masked, non-inferiority phase 3 trial. Lancet Respir Med 2025;epublished July 15th
- Maitland. Intravenous Rehydration for Severe Acute Malnutrition with Gastroenteritis. NEJM 2025;epublished June 13th
- George. Effectiveness of nasal high-flow oxygen during apnoea on hypoxaemia and intubation success in paediatric emergency and ICU settings: a randomised, controlled, open-label trial. Lancet Respir Med 2025;epublished March 21st
- Waldron. Procalcitonin-guided duration of antibiotic treatment in children hospitalised with confirmed or suspected bacterial infection in the UK (BATCH): a pragmatic, multicentre, open-label, two-arm, individually randomised, controlled trial. Lancet Child Adolesc Health 2025;epublished January 8th
- Writing and Steering Committees for the DESIGNATION–Investigators. Intraoperative driving pressure-guided high PEEP vs standard low PEEP for postoperative pulmonary complications. JAMA 2025;epublished December 3rd
- PROTHOR Collaborative Group. Effects of intraoperative higher versus lower positive end-expiratory pressure during one-lung ventilation for thoracic surgery on postoperative pulmonary complications (PROTHOR): a multicentre, international, randomised, controlled, phase 3 trial. Lancet Respir Med 2025;epublished November 12th
- Saugel. Individualized Perioperative Blood Pressure Management in Patients Undergoing Major Abdominal Surgery. The IMPROVE-multi Randomized Clinical Trial. JAMA 2025;epublished October 12th
- Kant. Proactive vs Reactive Treatment of Hypotension During Surgery. The PRETREAT Randomized Clinical Trial. JAMA 2025;epublished October 12th
- Greco. Effect of Remote Ischemic Preconditioning on Myocardial Injury in Noncardiac Surgery: the PRINCE Randomized Clinical Trial. Circulation 2025;epublished Circulation June 13th
- Monaco. A Randomized Trial of Acute Normovolemic Hemodilution in Cardiac Surgery. N Engl J Med 2025;epublished June 12th
- Karkouti. Prothrombin Complex Concentrate vs Frozen Plasma for Coagulopathic Bleeding in Cardiac Surgery. The FARES-II Multicenter Randomized Clinical Trial. JAMA 2025;epublished March 29th
- Spence. Benzodiazepine-Free Cardiac Anesthesia for Reduction of Postoperative Delirium: A Cluster Randomized Crossover Trial. JAMA Surg 2025;160(3):286-294
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Last updated December 19th, 2025