Sander Rozemeijer is an anesthesiology resident at Amsterdam UMC in the Netherlands. After graduating medical school with honours in 2018, he started his doctoral program in the field of Intensive Care Medicine. His research focusses on the effects of vitamin C in ischemia-reperfusion injury. He coordinated the multicenter VITaCCA-trial, investigating the effect of early high-dose vitamin C in post-cardiac arrest patients.

Dr Angelique de Man is an intensivist at Amsterdam UMC in the Netherlands. She has extensive experience in clinical and, since she is also a medical biologist, also in translational research. Her domains of expertise in research comprise hyperoxia, cardiac arrest, vitamin C and micronutrients in critical care setting.

She coordinated the O2-ICU trial, investigating low-normal vs high-normal PaO2 target in 400 critically ill patients with SIRS (JAMA 2021). She was coauthor of the micronutrient guidelines (doi: 10.1016/j.clnu.2022.02.015) and is currently leader of the micronutrients working group of the ESICM. Furthermore, she is a member of the ESPEN special interest group for micronutrients. Together with her PhD-student Sander Rozemeijer, she coordinated the VITaCCA trial, an RCT investigating the effect of 2 different doses (3 and 10 g per day) of intravenously administered vitamin C versus placebo in 270 post cardiac arrest patient. Furthermore, she recently received the MSCA-DN grant of the EU for the BIO-MICRO (Biomarkers and Intervention Outcomes in Micronutrient Optimization) project. In this project 13 PhDs in 4 different countries (Netherlands, Germany, Ireland and Italy) will develop new analytics to enable reliably determination of functional micronutrient body status, investigate potential subphenotypes of patients most likely to benefit from micronutrient supplementation and enable guidance with appropriate timing of micronutrient therapy.

Dr. Jonathan Casey is a pulmonary and critical care physician and clinical researcher with a focus on conducting pragmatic comparative effectiveness clinical trials. He is the director of the Coordinating Center for the Pragmatic Critical Care Research Group, which has led more than 25 trials, enrolling more 50,000 patients. He has published more than 190 manuscripts, including 20 manuscripts in The New England Journal of Medicine or JAMA, and his research has identified multiple beneficial interventions that have changed care for critically ill patients around the world. 

Dr. Casey also serves as Co-PI of the NCATS-funded Vanderbilt Trial Innovation Center which supports the development and conduct of multi-center trials across the United States. He cares for patients in the Vanderbilt University Medical Intensive Care Unit.

Matthew W. Semler MD, MSc is an Associate Professor of Medicine, Anesthesiology, and Biomedical Informatics at Vanderbilt University where he practices as a critical care physician, serves as Associate Director of the Medical Intensive Care Unit, and directs the Center for Learning Healthcare. Dr. Semler co-directs the Pragmatic Critical Care Research Group, a network of emergency medicine, anesthesia, and critical care clinicians and researchers at 25 centers across the US that embeds pragmatic trials into clinical care to determine which treatments produce the best patient outcomes.

Randomized trials he has helped lead, including 15 published in the New England Journal of Medicine or JAMA, have identified effective treatments in the fields of fluid management, tracheal intubation, and respiratory support.