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Critical Care Reviews Meeting 2025

The best critical care trials in the world

June 11th to 13th, 2025  |  Titanic Belfast

Trial Results Presenters

First presentations of major trials results


Marion Moseby-Knappe

Senior Investigator, TTM2

Dr. Marion Moseby-Knappe is a Consultant Neurologist at the Department of Neurorehabilitation at Skåne University Hospital in Lund, Sweden. She holds a PhD within neurological prognostication after cardiac arrest from Lund University. Her main research interest is understanding brain injury and optimizing the prediction of outcome after cardiac arrest. Together with the team at Lund University Centre for Cardiac Arrest, she has published prognostic studies on brain injury biomarkers, neuroimaging, neurophysiology and neurological prognostication within the TTM1 and TTM2 trials.

Marion is responsible for the neurological prognostication within the international multicentre STEPCARE trial, and principal investigator of the EARLY-NEURO substudy combining biomarkers, computed tomography and electroencephalography for early neuroprognostication.

Niklas Nielsen

Niklas Nielsen

Chief Investigator, TTM2

Niklas Nielsen is professor of anesthesiology and intensive care at Lund University, Sweden and vice dean of the Medical Faculty. He has during the last two decades been leading large international cardiac arrest studies and trials building a network of over 80 hospitals in 18 countries focusing on targeted temperature management for ischemic brain damage and prognostication of outcome. 

The trials, TTM1 and TTM2, have had considerable impact on clinical guidelines worldwide for post cardiac arrest care, neuroprognostication and follow-up. He is now chief investigator for the STEPCARE project, a randomizied trial with 3500 participants looking into fever management, sedation strategies and level of mean arterial pressure after cardiac arrest.

He would love to sail to the Critical Care Reviews Belfast meeting.

Prof Edward Litton

Edward Litton

Co-Chief Investigator, NOTACS Trial

Clinical Professor Litton is an Intensive Care Specialist and Director of ICU research at Fiona Stanley Hospital, Perth, Western Australia. He is a NHMRC Research Fellow who leads research programs in optimising recovery after ICU, diagnosing and treating sepsis, gut microbiome changes of critical illness microbiome, and improving ICU sleep. He is the Clinical Director of the Australia and New Zealand Intensive Care Society (ANZICS) Critical Care Resources Registry that monitors ICU resourcing to improve safety and quality. Prof Litton has received over $12M AUD in competitive grant funding as Chief Investigator and has published more than 150 manuscripts in the peer review literature.

Andrew Klein

Co-Chief Investigator, NOTACS Trial

Andrew Klein is a Consultant at Royal Papworth Hospital Deparment of Anaesthesia and Intensive Care. He is the former Editor-in-Chief of the journal Anaesthesia and the Vice-President of the Association of Anaesthetist.

Andrew’s main research interests are improving outcomes after major surgery and iron/B12 deficiency and anaemia. Andrew is a keen cricket supporter and lifelong and long-suffering West Ham fan.

Paul Mouncey

Co-Chief Investigator, UK-ROX

Paul is Co-Director, and Clinical Trials Unit Director, at the Intensive Care National Audit & Research Centre (ICNARC) . Paul is an epidemiologist with over 20 years’ experience of conducting multicentre randomised clinical trials, initially in Cancer, but at ICNARC focussed in adult and paediatric critical care. Paul is the Joint-Chief Investigator for the UK-ROX trial - a highly challenging trial within the critical care setting, using extensive data collected routinely by the national clinical audit for critical care (Case Mix Programme) database.

Paul led the development of the NIHR-funded PIVOTAL adaptive platform trial evaluating multiple interventions in paediatric critical care and sits on the REMAP-CAP International Trial Steering Committee. He sits on both the NIHR Critical Care National Specialty Group, which has responsibility for overseeing delivery of studies on the NIHR portfolio for critical care, and the UK Critical Care Research Group.

Twitter:  @PaulMouncey

Daniel Martin

Co-Chief Investigator, UK-ROX

Daniel is Professor of Perioperative and Intensive Care Medicine at the University of Plymouth and a consultant in intensive care medicine at Derriford Hospital in Plymouth. He has a PhD in applied physiology from University College London and his main research interest is focused on the physiology and clinical implications of too much or too little oxygen. He has been involved in several research expeditions to high altitude and in 2007 summited Mount Everest with the Xtreme Everest team; an blood gas taken from him near the summit showed one of the lowest arterial oxygenation readings ever recorded in a human. Daniel is a chief investigator for the UK-ROX trial evaluating conservative oxygen therapy in mechanically ventilated patients and the EXAKT sub-study to assess the accuracy of pulse oximeters in patients with different skin tones. He is the editor in chief of the Journal of the Intensive Care Society and in 2016 was awarded Officer of the Order of the British Empire (OBE), for services to the prevention of infectious diseases.

Kathryn Maitland

Chief Investigator, GASTROSAM Trial

Kathryn Maitland is Professor of Paediatrics at Imperial College, London and is based full-time in East Africa, where she leads a research group whose portfolio includes severe malaria, bacterial sepsis and severe malnutrition in children. Her team conducted the largest trial in critically children ever undertaken in Africa (FEAST trial) examining fluid resuscitation strategies in children with severe febrile illness, showing that fluid boluses increased mortality. She has also lead the landmark TRACT trial, investigating transfusion and other treatment strategies in 3800 African children severe life-threatening anaemia, and the COAST trial (Children Oxygenation Administration Strategies Trial) examining the optimum oxygen saturation threshold for which oxygen should be targeted and how best to administer oxygen, by high flow or low flow, in 4200 severely ill African children. In recognition of her contribution to medical research and healthcare she was recently elected to Fellowship of the Academy of Medical Sciences.

Twitter:  @KathMaitland

Elizabeth George

Statistician, GASTROSAM Trial

Dr. Elizabeth George is a statistician and researcher with 15 years of experience working on clinical trials focused on acutely ill children presenting to hospitals in Africa. She has contributed to award-winning large trials that have challenged the status quo, led to changes in guidelines, and provided crucial evidence supporting existing guidelines. These trials have sparked numerous global debates and discussions. Her work has included trials on fluid resuscitation for pediatric shock, blood transfusion volumes for severe anemia, antibiotics for severe malaria and bacterial co-infection, and fluids for children with gastroenteritis with or without severe malnutrition.

Dr. George leads subsequent analyses, publications, and dissemination projects from these trials, developing analysis plans and collaborating closely with colleagues. She has also served as a trial statistician for smaller trials that have clarified underlying mechanisms and helped inform future research.

Dr. George is passionate about conducting high-quality clinical trials to answer critical questions and provide evidence for treatment guidelines for children presenting to hospitals in Africa.

Twitter:  @lcgeorge13

Lee-anne Chapple

Senior Investigator, TARGET Protein Trial

Lee-anne Chapple is the Senior Critical Care Dietitian at the Royal Adelaide Hospital, and Associate Professor at the University of Adelaide in Australia. She leads the intensive care nutrition research program at the Royal Adelaide Hospital, focusing on protein delivery and utilisation, post-ICU nutrition, and recovery.

A/Prof Chapple has collaborated on more than 90 research publications and received more than $10 million Australian dollars in research funding. She was the post-doctoral research fellow and co-Project Manager for the TARGET Protein trial. 

Twitter:  @LSChapple

Matthew Summers

Senior Investigator, TARGET Protein Trial

Matt is a Research Dietitian at the Royal Adelaide Hospital and PhD candidate at University of Adelaide. Matt has worked within the Intensive Care Unit Research Department at the Royal Adelaide Hospital for over 15 year and most recently co-project managed the TARGET Protein Trial.

Matt commenced his PhD in July 2022 and is anticipated to complete this by the end of 2025. The focus of Matt’s doctoral research is to evaluate enteral protein delivery and protein metabolism in the critically ill.

Twitter:  @msummo2

Adam Deane

Senior Investigator, TARGET Protein Trial

Once he appreciated that being both scared of short pitched bowling and having a weakness against the swinging ball outside off-stump were major impediments to his dream of batting first drop for the Australian cricket team, Adam transitioned his career aspirations to medicine.

He currently pays the mortgage with employment as Staff Specialist, Head of Intensive Care Unit Research, and Deputy Director Intensive Care Unit at The Royal Melbourne Hospital. His academic appointments include Professorial Fellow in Intensive Care and Deputy Director of the Department of Critical Care Medicine at the University of Melbourne. From an earlier age, Adam developed a passion for frozen milk-based foods that stimulate sweet taste receptors. He continues to enjoy
following this passion whenever possible.

Twitter:  @MelbourneICU

Editorialists & Panellists


Journal Editors


Darren Taichman

Darren Taichman

Deputy Editor, NEJM

Darren Taichman, MD, PhD, MACP is a pulmonary and critical care physician who practices and teaches at the University of Pennsylvania.  At Penn, he was Director of the intensive care unit and led research programs focused on critical care medicine and pulmonary vascular disease.  Dr. Taichman’s editorial work began in 2007 at the Annals of Internal Medicine, where he was the Executive Editor as well as Vice President of the American College of Physicians, the largest medical specialty organization in the United States.  He served as Secretary of the International Committee of Medical Journal Editors from 2014 – 2021.  In 2020, Dr. Taichman was appointed Deputy Editor and Online Editor of the New England Journal of Medicine, as well as the Executive Strategy Editor for the NEJM Group.  He continues to teach and see patients at the University of Pennsylvania, with a specific focus on the treatment of pulmonary hypertension. 

Chris Seymour

Christopher Seymour

Associate Editor for Critical Care, JAMA

Dr. Seymour is an Associate Professor in the Departments of Critical Care, Emergency Medicine, and Clinical and Translational Science at the University of Pittsburgh School of Medicine. Over the past 10 years, his research program has focused on clinical and translational studies involving sepsis, biomarkers, and large electronic health record databases. Dr. Seymour completed his NIGMS Career Development Award (K23), mentored by Dr. Derek Angus, titled “Prehospital identification of high-risk sepsis.” This successful award led to funding of a NIH/NIGMS R35 ESI-Merit Investigator Research Award, “Sepsis endotypes during emergency care.” He is Director of the Clinical and Translational Science Program in the Department of Critical Care Medicine, member of the International Sepsis Forum (ISF), and Associate Editor for Critical Care at JAMA. His research has been published in the New England Journal of Medicine, JAMA, and The Lancet, among others.

Twitter:  @seymoc

Statisticians